Sökning: "IGFIR"

Hittade 3 avhandlingar innehållade ordet IGFIR.

  1. 1. Growth hormone and somatolactin function during sexual maturation of female Atlantic salmon

    Författare :Susana Benedet Perea; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Growth hormone; somatolactin; insulin-like growth factor I; GH; SL; IGFI; GHR; SLR; IGFIR; ovary maturation; reproduction; Atlantic salmon; spawning; pituitary;

    Sammanfattning : Background and aims: The growth hormone-insulin-like growth factor I (GH-IGF-I) system is known to act during sexual maturation of female salmonids, but the specific roles are not known. Somatolactin (SL) is a pituitary hormone closely related to GH and is only found in fish. In some species, including salmonids, there are two forms, SLa and SLß. LÄS MER

  3. 2. Insulin resistance and IGF-I sensitivity in vascular cells - impact of hybrid receptors : With special regard to diabetes

    Författare :Git Johansson; Hans Arnqvist; Pierre De Meyts; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Diabetic complications largely affect the circulation and are associated with resistance to insulin and altered levels of insulin-like growth factor-I (IGF-I). Insulin resistance and altered IGF-I levels are also associated with vascular disease. LÄS MER

  4. 3. The use of IGF-IR inhibitors in cancer therapy : a potential approach for sensitizing tumor cells to ionizing radiation

    Författare :Daria Cosaceanu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This study focused on insulin-like growth factor I receptor (IGF-IR), considered as a promising therapeutic target for cancer treatment. We were in particular interested in the involvement of IGF-IR in tumor cells response to radiation and we tried to provide the rationale for a combined therapy of IFG4R inhibitors with radiation in order to improve the therapeutic outcome. LÄS MER