Sökning: "IGF-IR"

Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet IGF-IR.

  1. 1. The Regulation of Growth and Survival in Human Multiple Myeloma Cells by IGF-I Receptor Signaling

    Författare :Thomas Strömberg; Helena Jernberg Wiklund; Kenneth Nilsson; Anders Waage; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; Multiple myeloma; IGF-IR; apoptosis; somatostatin; octreotide; dexamethasone; GSK-3; mTOR; rapamycin; RTK inhibitor; Patologi; Pathology; Patologi;

    Sammanfattning : Multiple myeloma (MM) is an incurable B-cell malignancy mainly localized to the bone marrow. Our aim was to examine the growth- and survival-promoting role of the IGF-IR and its downstream signaling components in MM cells to identify potential targets for therapy. LÄS MER

  3. 2. The use of IGF-IR inhibitors in cancer therapy : a potential approach for sensitizing tumor cells to ionizing radiation

    Författare :Daria Cosaceanu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This study focused on insulin-like growth factor I receptor (IGF-IR), considered as a promising therapeutic target for cancer treatment. We were in particular interested in the involvement of IGF-IR in tumor cells response to radiation and we tried to provide the rationale for a combined therapy of IFG4R inhibitors with radiation in order to improve the therapeutic outcome. LÄS MER

  4. 3. Insulin resistance and IGF-I sensitivity in vascular cells - impact of hybrid receptors : With special regard to diabetes

    Författare :Git Johansson; Hans Arnqvist; Pierre De Meyts; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Diabetic complications largely affect the circulation and are associated with resistance to insulin and altered levels of insulin-like growth factor-I (IGF-I). Insulin resistance and altered IGF-I levels are also associated with vascular disease. LÄS MER

  5. 4. Expression and function of IGF-I and insulin receptors in human micro- and macrovascular cells

    Författare :Simona I. Chisalita; Hans J. Arnqvist; Torbjorn Lindström; Per-Anders Jansson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Insulin-like growth factor and insulin are phylogenetically closely related polypeptides and have large structural and biological similarities. Low circulating insulin-like growth factor-I (IGF-I), diabetes as well as insulin resistance have been implicated in the pathogenesis of cardiovascular disease, but the mechanisms involved are still not clear. LÄS MER

  7. 5. Interaction between insulin and IGF-I receptors in insulin sensitive and insulin resistant cells and tissues

    Författare :Karolina Bäck; Hans Arnqvist; Hans Tornqvist; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Insulin and insulin-like growth factor I (IGF-I) are two related peptides with similar structure. They mediate their effects by binding to their respective receptor, the insulin receptor (IR) and the IGF-I receptor (IGF-IR) and induce intracellular signalling cascades resulting in metabolic or mitogenic effects. LÄS MER