Sökning: "IFN-[alpha]"

Visar resultat 1 - 5 av 25 avhandlingar innehållade ordet IFN-[alpha].

  1. 1. Regulation of Type I Interferon Production in Plasmacytoid Dendritic Cells : Effect of Genetic Factors and Interactions with NK Cells and B Cells

    Författare :Olof Berggren; Maija-Leena Eloranta; Niels Heegaard; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic lupus erythemtosus; IFN-alpha; autoimmunity; immune complex; single nuclear polymorphisms; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The type I interferon (IFN) system plays a central role in the etiopathogenesis of many autoimmune diseases, e.g. systemic lupus erythematosus (SLE). Activation of the type I IFN system in SLE is promoted by endogenous nucleic acid-containing immune complexes (ICs) which stimulate plasmacytoid dendritic cells (pDCs). LÄS MER

  3. 2. Interferons in immunity to chlamydia pneumoniae

    Författare :Antonio Carlos Gigliotti (Tony) Rothfuchs; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Chlamydia pneumoniae; TLR; IFN-alpha beta; IFN-gamma; macrophages; T cells;

    Sammanfattning : The cytokine IFN-gamma is the architect behind an amazing immunological program of host resistance to intracellular bacterial and protozoan infections. IFN-gamma activates macrophages, making them into inhospitable habitats for parasites attempting to grow inside them. LÄS MER

  4. 3. Humoral and cellular immune responses to proteins encoded by the hepatitis C virus

    Författare :Zhu-Xu Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HCV; genotype; antibody; IFN-alpha; MHC; haplotype; ScFv; peptide; T cell;

    Sammanfattning : The hepatitis C virus (HCV) was the first described human pathogen of the hepaciviruses, a new genus within the flaviviridae family. A characteristic feature of HCV is that it has a high genetic heterogenecity. It is believed that the immune response is of vital importance to prevent, control, and to eradicate HCV infections. LÄS MER

  5. 4. Studies of the recognition and activation of natural killer cells

    Författare :Clas Une; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NK cells; activation; cytotoxicity; IFN-[gamma] IFN-[alpha] [beta]; IL-12; G-PI; MHC class I;

    Sammanfattning : Natural killer (NK) cells mediate part of the innate immune response that impedes the spread of invading microorganisms and shapes the downstream adaptive immune response. NK cells spontaneously kill tumor cells and other cells upon contact. Killing requires engagement of germline encoded receptors that mediate positive and negative signals. LÄS MER

  7. 5. Monoclonal antibodies and cytokines for therapy of patients with advanced colorectal carcinoma : a clinical and immunological study

    Författare :Anna-Lena Hjelm Skog; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Colorectal carcinoma; Monoclonal antibodies; IL-2; IFN-[alpha]; GM-CSF; cytokine antibodies; neopterin; sIL-2R; immune suppression;

    Sammanfattning : There is a great need for developing and improving treatment alternatives in colorectal carcinoma (CRC). The tumour associated antigen (TAA) GA733/CO17-1A is expressed by more than 90% of all CRCs, on the majority of both primary and metastatic CRC cells. LÄS MER