Sökning: "Dynamic kinetic resolution DKR"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden Dynamic kinetic resolution DKR.

1. 1. Dynamic Systems : Enzymatic Synthesis, Exchange Reactions and Applications in Materials Science

   Författare :Yang Zhang; Olof Ramström; Mihail D. Barboiu; KTH; []
   Nyckelord :constitutional dynamic chemistry; reversible reactions; kinetic resolution; dynamic kinetic resolution; enzyme catalysis; lipase; asymmetric synthesis; racemization; oxazolidinone; organogel; enamine; nitroaldol reaction.;

   Sammanfattning : This thesis is divided into three parts, revolving around the developments of dynamic systems utilized in dynamic kinetic resolution (DKR) and constitutional dynamic chemistry (CDC).The first section gives an introduction to constitutional dynamics, the core concept of this thesis. LÄS MER

3. 2. Chemoenzymatic Resolution in Dynamic Systems : Screening, Classification and Asymmetric Synthesis

   Författare :Yan Zhang; Olof Ramström; Sabine Flitsch; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; constitutional dynamic chemistry; dynamic systemic resolution; dynamic kinetic resolution; enzyme catalysis; transesterification; enzyme promiscuity; asymmetric synthesis; pattern recognition; self-inhibition.;

   Sammanfattning : This  thesis  is  divided  into  four  parts,  all  centered  around  Constitutional Dynamic  Chemistry  (CDC)  and  Dynamic  Kinetic  Resolution  (DKR)  using biocatalysts for selective transformations, and their applications in screening of bioactive compounds, organic synthesis, and enzyme classification.   In  part  one,  an  introduction  to  CDC  and  DKR  is  presented,  illustrating  the basic  concepts,  practical  considerations  and  potential  applications  of  such dynamic systems, thus providing the background information for the studies in the following chapters. LÄS MER

4. 3. Ruthenium-Catalyzed Hydrogen Transfer Reactions : Mechanistic Studies and Chemoenzymatic Dynamic Kinetic Resolutions

   Författare :Madeleine Warner; Jan-Erling Bäckvall; Andreas Pfaltz; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hydrogen transfer; ruthenium catalysis; kinetic resolution; dynamic kinetic resolution; racemization; asymmetric synthesis; organisk kemi; Organic Chemistry;

   Sammanfattning : The main focus of this thesis lies on transition metal-catalyzed hydrogen transfer reactions. In the first part of the thesis, the mechanism for racemization of sec-alcohols with a ruthenium complex, Ru(CO)2Cl(η5-C5Ph5) was studied. LÄS MER

5. 4. Asymmetric transformation of ß- and γ-functionalized alcohols : Study of combined ruthenium-catalyzed racemization and enzymatic resolution

   Författare :Annika Träff; Jan-Erling Bäckvall; Reko Leino; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kinetic resolution; dynamic kinetic resolution; kinetic asymmetric transformation; dynamic kinetic asymmetric transformation; enzyme catalysis; racemization; asymmetric synthesis; chlorohydrin; cyano acetate; amino alcohol; metalloenzyme; bifunctional catalytic system; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

   Sammanfattning : The major part of this thesis describes the asymmetric synthesis of β- and γ-amino alcohols through the combination of ruthenium catalyzed racemization and enzymatic kinetic resolution. The dynamic kinetic resolution, DKR, protocol for chlorohydrins was improved by employing Bäckvall’s catalyst, which is a base activated racemization catalyst, in combination with Burkholderia cepacia lipase. LÄS MER

7. 5. Enantioselective Synthesis of Sec-Alcohol Derivatives and Diols via Combined Ruthenium and Enzyme Catalysis

   Författare :Linnéa Borén; Jan-Erling Bäckvall; Romas Kazlauskas; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; catalysis; kinetic resolution; ruthenium catalyst; Dynamic kinetic resolution; Dynamic Kinetic Asymmetric Transformation; Organic chemistry; Organisk kemi; Organic Chemistry; organisk kemi;

   Sammanfattning : The first part of this thesis describes the synthesis of enantiopure secondary alcohol derivatives. These syntheses are carried out via the combination of an enzyme as a resolution catalyst and a ruthenium catalyst as a racemization catalyst, in what is called dynamic kinetic resolution (DKR). LÄS MER