Sökning: "David Brayden"

Hittade 2 avhandlingar innehållade orden David Brayden.

1. 1. Oral delivery of macromolecules formulated with permeation enhancers

   Författare :Staffan Berg; Christel Bergström; Nigel Davies; Andreas Hugerth; David Brayden; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oral peptide delivery; permeation enhancer; sodium caprate; oral drug delivery; intestinal absorption of macromolecules; Biofarmaci; Biopharmaceutics; Galenisk farmaci; Pharmaceutics;

   Sammanfattning : Therapeutic macromolecules including peptides, proteins, and nucleotide-based ones (such as antisense oligonucleotides and RNAs) have great potential as drug candidates. One drawback is that they typically need to be administered parenterally via subcutaneous, intramuscular or intravenous injections. LÄS MER

3. 2. Effects of Microparticulate Drug Delivery Systems : Tissue Responses and Transcellular Transport

   Författare :Eva Ragnarsson; Per Artursson; Lucia Lazorova; David Brayden; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; microparticles; vaccine; pDNA vaccine; cationic polymer; gene expression analysis DNA array ; Caco-2; follicle-associated epithelium FAE ; M cell; transcytosis; Yersinia pseudotuberculosis; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

   Sammanfattning : Over the past decade, the development of macromolecular drugs based on peptides, proteins and nucleic acids has increased the interest in microparticulate drug delivery, i.e., the delivery of drug systems in the nanometer and micrometer ranges. LÄS MER