Sökning: "DNA distribution"

Visar resultat 1 - 5 av 298 avhandlingar innehållade orden DNA distribution.

1. 1. Ribonucleotides in DNA - Application in genome-wide DNA polymerase tracking and physiological role in eukaryotes

   Författare :Katrin Kreisel; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ribonucleotides; DNA instability; DNA polymerase eta; nuclear DNA; mitochondrial DNA;

   Sammanfattning : The genetic code in the eukaryotic cell is stored in the form of DNA, which is more resistant to hydrolysis than RNA. Replication fidelity and DNA repair mechanisms are in place to ensure genomic integrity to preserve the information encoded. LÄS MER

3. 2. Microfluidic Preparation and Transport of Long DNA using Pillar Arrays

   Författare :Oskar Ström; NanoLund: Centre for Nanoscience; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microfluidics; Deterministic Lateral Displacement; DNA Separation; Elastic Turbulence; Micro-pillar arrays; DNA Sample Preparation; Lab-on-a chip; elastic waves; Sample Preparation; DNA Isolation; bumper array; Fysicumarkivet A:2023:Ström;

   Sammanfattning : This thesis presents a set of microfluidic tools and experimental studies for preparing (> 20 kbp) for genetic analysisas well as the transport of high-concentration, long-DNA solutions in pillar arrays.Long-DNA sample preparation with conventional gel-based techniques is slow (tens of hours to days) and laborious. LÄS MER

4. 3. Phylogeny, taxonomy and species delimitation of water mites and velvet mites

   Författare :Jeanette Stålstedt; Johannes Bergsten; Fredrik Ronquist; Joanna Mąkol; Ashley Dowling; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Acariformes; Parasitengona; Hydrachnidia; Trombidia; water mites; velvet mites; taxonomy; cryptic species; species delimitation; DNA; GMYC; experimental rearing; new synonyms; distribution; phylogeny; revised classification; Systematic Zoology; zoologisk systematik och evolutionsforskning;

   Sammanfattning : This study is part of the Swedish Taxonomy Initiative (STI) - one of the most ambitious all taxa biodiversity inventories in the world. One of the pillars in STI is to support taxonomic research on the most neglected taxonomic groups with the aim to lift the level of knowledge of biodiversity in the country. LÄS MER

5. 4. Statistical Modelling of Cell Cycle Dynamics Analysis and Interpretation of BrdUrd DNA FCM-Derived Data

   Författare :Sara Larsson Lönn; Matematisk statistik; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; G2 phase duration; DNA replication; flow cytometry; Natural science; Naturvetenskap; S phase duration; DNA distribution; branching processes; cell cycle kinetics;

   Sammanfattning : It it of great importance to increase the knowledge of various cell cycle kinetic parameters and the objective of this thesis is to use stochastic models to interpret Bromodeoxyuridine (BrdUrd) DNA Flow Cytometry (FCM) derived data in order to estimate such parameters. The cell cycle is the process of growth and division that is essential for an organism to increase in size. LÄS MER

7. 5. Induction and repair of clustered DNA damage sites after exposure to ionizing radiation

   Författare :Andris Abramenkovs; Bo Stenerlöw; Peter O'Neill; Uppsala universitet; []
   Nyckelord :NHEJ; DSB repair; clustered DNA damage; DNA repair; DNA-PKcs; HSCS; Ra-223; ionizing radiation; Medicinsk vetenskap; Medical Science;

   Sammanfattning : The mechanisms that maintain genomic stability safeguard cells from constant DNA damage produced by endogenous and external stressors. Therefore, this thesis aimed to specifically address questions regarding the requirement and involvement of DNA repair proteins in the repair of various types of radiation-induced DNA damage. LÄS MER