Sökning: "Bfl-1"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet Bfl-1.

  1. 1. Regulation of Mast Cell Survival

    Författare :Christine Möller; Gunnar Nilsson; Alf Grandien; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; mast cell; A1; Bfl-1; Bim; Bcl-2 family members; basophil; SCF; forkhead; survival; Patologi; Pathology; Patologi;

    Sammanfattning : Mast cells are long-lived effector cells of importance for both acute and chronic inflammations. Mast cells can be activated in many different ways, leading to the release of inflammatory mediators. In contrast to most other inflammatory cells, activated mast cells have the capacity to recover, regranulate and thereby be activated again. LÄS MER

  3. 2. Why Is It So Hard to Kill a Mast Cell?A Study of Mast Cell Activation and Survival

    Författare :Xiang Zou; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; A1; allergy; apoptosis; Bfl-1; degranulation; FcepsilonRI; IgE; inflammation; mast cells; nerve growth factor; regranulation; TrkA; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Mast cells have a long life in tissues, where they are involved in inflammatory and hypersensitivity reactions. Activation through cross-linking of the high-affinity IgE-receptor (FcεRI) is a primary stimulus capable of degranulating mast cells, contributing to symptoms of allergy. LÄS MER

  4. 3. Molecular characterization of apoptosis in B-cell chronic lymphocytic leukemia

    Författare :Anna Olsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :B-CLL; apoptosis; TRAIL; FLIP; Bmf; Bfl-1;

    Sammanfattning : B-cell chronic lymphocytic leukemia (B-CLL), characterized by an accumulation of monclonal B cells, is the most common adult leukemia in the Western world. Defective apoptosis is considered to contribute to cell accumulation, disease progression and resistance to therapy in BCLL. LÄS MER

  5. 4. Regulation of mast cell function and survival in health and disease

    Författare :Katarina Lyberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mast cells are sentinels of danger but they are also the major effector cells in allergic disease causing the well-known allergic symptoms caused by their mediators such as histamine and prostaglandin D2 that are released upon activation. Mastocytosis is a disease characterized by the clonal expansion of mast cells in the skin and/or other organs where the patients suffer from mediator-related symptoms and/or organ failure due to mast cell infiltration. LÄS MER

  7. 5. The impact of Bcl-2 family members on mast cell survival and apoptosis

    Författare :Maria Ekoff; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mast cells are long-lived effector cells of the immune system perhaps best known for their involvement in allergic diseases. There are several acute and chronic inflammations where mast cell accumulation, activation and release of mediators are important for the initiation and perpetuation of the inflammation. LÄS MER