Sökning: "TrkA"

Visar resultat 1 - 5 av 35 avhandlingar innehållade ordet TrkA.

1. 1. Neuroblastoma Cell Differentiation: The Role of Neurotrophin Receptor Signaling and N-myc Expression

   Författare :Anders Edsjö; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytologi; onkologi; cancer; oncology; cancerology; Cytology; N-myc.; trkC; trkB; trkA; neurotrophins; Neuroblastoma; sympathetic nervous system;

   Sammanfattning : Neuroblastoma is a tumor of sympathetic nervous system derivation, mostly afflicting young children. This thesis is focused on a group of receptor proteins for neurotrophic factors, the Trk family, and on N-Myc, a transcription factor, all important in the formation of the sympathetic nervous system as well as in determining neuroblastoma patient outcome. LÄS MER

3. 2. Characterization of the perturbed differentiation in neuroblastoma, aided by the analysis of normal sympathetic nervous system development

   Författare :Carolina Gestblom; Lund Wallenberg Neurocentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; development; TrkA; apoptosis; proliferation; sympathetic nervous system; neuronal; paraganglia; neuroblastoma; chromaffin; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : Neuroblastoma is a pediatric tumor derived from cells in the sympathetic nervous system. In an attempt to explain the heterogeneous clinical behavior of neuroblastoma tumors, neuroblastomas have been characterized with regard to their degree of sympathetic differentiation. LÄS MER

4. 3. Why Is It So Hard to Kill a Mast Cell?A Study of Mast Cell Activation and Survival

   Författare :Xiang Zou; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; A1; allergy; apoptosis; Bfl-1; degranulation; FcepsilonRI; IgE; inflammation; mast cells; nerve growth factor; regranulation; TrkA; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Sammanfattning : Mast cells have a long life in tissues, where they are involved in inflammatory and hypersensitivity reactions. Activation through cross-linking of the high-affinity IgE-receptor (FcεRI) is a primary stimulus capable of degranulating mast cells, contributing to symptoms of allergy. LÄS MER

5. 4. PACAP in adult sensory neurons - implications in injury and pain

   Författare :Helen Jongsma Wallin; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peripheral nerve injury; PAC1; PACAP; neurotrophin; neuropeptide; inflammatory pain; inflammation; gracile nuclei; DRG; formalin test; neurofysiologi; neuropsykologi; Neurologi; neurophysiology; neuropsychology; Neurology; trk;

   Sammanfattning : The data presented in this thesis deal with the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) in adult sensory neurons. We have used different injury and pain models to determine the involvement of PACAP during such conditions. The role of neurotrophins for PACAP expression was also investigated. LÄS MER

7. 5. Changes in human uterine innervation in term pregnancy and labor occurence and roles of neurotrophins and TRPV1

   Författare :Berith Karlsson Tingåker; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Uterus; corpus uteri; cervix uteri; pregnancy; labor pain; neurotrophins; NGF; TRPV1; sensory corpuscles; human.;

   Sammanfattning : Objective: Cervical ripening, is a prerequisite for successful labor, which is often very painful and involves an inflammatory reaction. However, little is presently known con-cerning nerve-related changes in the human uterus during labor and the fundamental hy-pothesis tested here was that labor pain emanates primarily from the cervix uteri. LÄS MER