Sökning: "BMAA"

Visar resultat 6 - 10 av 12 avhandlingar innehållade ordet BMAA.

1. 6. Detection, transfer and role of an environmentally spread neurotoxin (BMAA) with focus on cyanobacteria and the Baltic Sea region

   Författare :Lotta Berntzon; Birgitta Bergman; Geoffrey Codd; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; β-N-methylamino-L-alanine; BMAA; cyanobacteria; Baltic Sea; blooms; neurotoxin; neurodegenerative diseases; amyotrophic lateral sclerosis; ALS; nitrogenase; nitrogen fixation; Plant Physiology; växtfysiologi;

   Sammanfattning : β-N-methylamino-L-alanine (BMAA) is one of the more recently discovered bioactive compounds produced by cyanobacteria. BMAA is a non-protein amino acid reported present in human brain tissues of patients deceased from a neurodegenerative disease, such as Alzheimer´s disease or amyotrophic lateral sclerosis (ALS). LÄS MER

3. 7. Phylogeny, diversity and toxin production related to cyanobacterial symbioses

   Författare :Dimitra Papaefthimiou; Ulla Rasmussen; Kaarina Sivonen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Azolla; BMAA; cyanobacteria; cyanobionts; cyanolichens; diversity; HPLC; Nostoc; phylogeny; symbiosis; Plant physiology; Växtfysiologi; växtfysiologi; Plant Physiology;

   Sammanfattning : Phylogeny and morphology were examined for the cyanobionts from the water fern Azolla and the cyanobacterial genus Nostoc originating from symbioses with different host plants (genera Gunnera, Cycas, Dioon, Encephalarthos, Macrozamia, and Anthoceros), the lichen genus Pannaria, and free-living Nostoc isolates from different habitats. Nostoc isolates of Pannaria formed a closely related group, but, in general, no monophyletic nature was attributed to the genus Nostoc, in contrast to the cyanobionts from Azolla which were contained in a unique monophyletic group. LÄS MER

4. 8. Amino acids with relevance to health, climate and the environment : Development of mass spectrometric methods

   Författare :Javier Zurita; Leopold Ilag; Ulrika Nilsson; Margareta Törnqvist; Natalia Tretyakova; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; amino acids; LC MS; fixed-charge derivatization; BMAA; chiral separation; pheromones; arctic aerosols; serum albumin adducts; benzo[a]pyrene diol epoxides; high-resolution MS; Analytical Chemistry; analytisk kemi;

   Sammanfattning : Amino acids play vital roles in health, either in their native form or chemically modified. Some studies have linked certain non-proteinogenic amino acids to neurodegenerative diseases, such as in the case of β-methylaminoalanine (BMAA). LÄS MER

5. 9. Mass Spectrometry of Biologically Active Small Molecules : Focusing on polyphenols, alkaloids and amino acids

   Författare :Zdeněk Spáčil; Leopold L. Ilag; Frantisek Turecek; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; LC-MS; LDI; Mass spectrometry; HPLC; UHPLC; polyphenols; phenolic acids; BMAA; Separation methods; Separationsmetoder; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

   Sammanfattning : The foci of this dissertation are on advanced liquid chromatography (LC) separation and mass spectrometry (MS) techniques for the analysis of small bioactive molecules. In addition to discussing general aspects of such techniques the results from analyses of polyphenols (PPs), alkaloids and amino acids published in five appended studies are presented and discussed. LÄS MER

7. 10. The neurotoxin β-N-methylamino-L-alanine (BMAA) : Sources, bioaccumulation and extraction procedures

   Författare :Sandra Ferreira Lage; Sara Rydberg; Ulla Rasmussen; Hanna Mazur-Marzec; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plant Physiology; växtfysiologi;

   Sammanfattning : β-methylamino-L-alanine (BMAA) is a neurotoxin linked to neurodegeneration, which is manifested in the devastating human diseases amyotrophic lateral sclerosis, Alzheimer’s and Parkinson’s disease. This neurotoxin is known to be produced by almost all tested species within the cyanobacterial phylum including free living as well as the symbiotic strains. LÄS MER