Sökning: "β-N-methylamino-L-alanine"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet β-N-methylamino-L-alanine.

1. 1. β-N-methylamino-L-alanine (BMAA)-induced neurotoxicity : Studies in vitro and in vivo

   Författare :Lisa Ersson; Malin Andersson; Eva B Brittebo; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BMAA; neurotoxin; neurodegeneration; cellular transport; metabolic profiling; protein-association; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : β-N-methylamino-L-alanine (BMAA) is a neurotoxic non-proteinogenic amino acid produced naturally by cyanobacteria, diatoms and dinoflagellates and it has been detected in samples from fresh and marine water from all over the world. It can bioaccumulate in fish and shellfish, and has a potential to biomagnify in a terrestrial food chain. LÄS MER

3. 2. The neurotoxin β-N-methylamino-L-alanine (BMAA) : Sources, bioaccumulation and extraction procedures

   Författare :Sandra Ferreira Lage; Sara Rydberg; Ulla Rasmussen; Hanna Mazur-Marzec; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plant Physiology; växtfysiologi;

   Sammanfattning : β-methylamino-L-alanine (BMAA) is a neurotoxin linked to neurodegeneration, which is manifested in the devastating human diseases amyotrophic lateral sclerosis, Alzheimer’s and Parkinson’s disease. This neurotoxin is known to be produced by almost all tested species within the cyanobacterial phylum including free living as well as the symbiotic strains. LÄS MER

4. 3. The neurotoxin β-N-methylamino-L-alanine (BMAA) and 2,4-diaminobutyric acid (DAB) : possible risk of human exposure, and the effect and function in diatoms

   Författare :Sea-Yong Kim; Sara Rydberg; Sandra Banack; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; växtfysiologi; Plant Physiology;

   Sammanfattning : The toxic secondary metabolites β-N-methylamino-L-alanine (BMAA) and 2,4-diaminobutyric acid (DAB) produced by phytoplankton groups such as cyanobacteria, diatoms and dinoflagellates are known to cause neurotoxicity in vertebrates. BMAA has been linked to development of the neurodegenerative diseases amyotrophic lateral sclerosis/Parkinsonism dementia complex (ALS/PDC) and Alzheimer's disease. LÄS MER

5. 4. Distribution and Long-term Effects of the Environmental Neurotoxin β-N-methylamino-L-alanine (BMAA) : Brain changes and behavioral impairments following developmental exposure

   Författare :Oskar Karlsson; Eva Brittebo; Nils Gunnar Lindquist; Erika Roman; Sandra Ceccatelli; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS PDC; Guam; Developmental neurotoxicity; Brain growth spurt; Behavior; Nonprotein amino acid; Excitotoxic; Cyanobacteria; Apoptosis; BMAA; environmental toxin; Algal blooming; Algblomning; algtoxin; alggift; hjärnutveckling; Toxicology; Toxikologi; Toxicology; Toxikologi;

   Sammanfattning : Many cyanobacteria are reported to produce the nonprotein amino acid β-N-methylamino-L-alanine (BMAA). Cyanobacteria are extensively distributed in terrestrial and aquatic environments and recently BMAA was detected in temperate aquatic ecosystems, e.g. the Baltic Sea. LÄS MER

7. 5. The novel sources of the neurotoxin BMAA in aquatic environments

   Författare :Sandra Lage; Sara Jonasson Rydberg; Ulla Rasmussen; Ann-Sofi Rehnstam-Holm; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; β-N-methylamino-L-alanine; diatoms; dinoflagellates; shellfish; cockles; PST; växtfysiologi; Plant Physiology;

   Sammanfattning : Neurotoxinet β -N-metylamino -L-alanin (BMAA) anses vara en potentiell miljöriskfaktor för utvecklingen av den neurodegenerativa sjukdomen amyotrofisk lateralskleros (ALS) och har en potentiell roll i flertalet andra neurodegenerativa sjukdomar. Sedan 2003, då det upptäcktes att BMAA produceras av den symbiotiska cyanobakterien Nostoc punctiforme  har flera andra BMAA producerande cyanobakteriearter identifierats. LÄS MER