Sökning: "ADAM17"

Hittade 3 avhandlingar innehållade ordet ADAM17.

  1. 1. Role of lactobacilli in Helicobacter pylori pathogenesis and host cell responses

    Författare :Hanna Gebreegziabher Gebremariam; Ann-Beth Jonsson; Keira Melican; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Helicobacter pylori; Inflammation; Lactobacillus; ADAM17; Proinflammatory cytokines; Lactate; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Helicobacter pylori is well adapted to the harsh environment of the human stomach, allowing it to persistently colonize the gastric mucosa of at least 50% of the global population for decades. Long-term colonization induces chronic inflammation that can eventually lead to development of peptic ulcer and gastric cancer. LÄS MER

  3. 2. Proteolytic processing of the Alzheimer APP protein family during neuronal differentiation

    Författare :Sofia Holback; Kerstin Iverfeldt; Nigel Hooper; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APP; APLP1; APLP2; differentiation; processing; retinoic acid; secretase; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Sammanfattning : Increased amyloid-β (Aβ) load in the brain, neurite degeneration, neuronal loss, and decreased levels of several neurotrophins are among the characteristics of Alzheimer’s disease (AD). Generation of Aβ occurs when the amyloid precursor protein (APP) is proteolytically processed by β- and γ-secretases in the amyloidogenic pathway. LÄS MER

  4. 3. The amyloid-β precursor protein (APP) and its adaptor protein Fe65 : Two key players in Alzheimer’s disease

    Författare :Preeti Menon; Anna-Lena Ström; Thorsten Müller; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; APP; Fe65; Meprinβ; α-secretase; APP processing; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the abnormal accumulation and aggregation of amyloid beta (Aβ) peptides within the brain. Generation of Aβ occur when the amyloid-beta precursor protein (APP) is proteolytically processed by β- and then γ-secretase in the amyloidogenic pathway. LÄS MER