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Visar resultat 1 - 5 av 12 avhandlingar som matchar ovanstående sökkriterier.

1. 1. On the influence of serotonin- and sex steroid-related genetic variation on mood, anxiety, personality, autism and transsexualism

   Författare :Susanne Henningsson; Göteborgs universitet; []
   Nyckelord :serotonin; 5-HTTLPR; TPH2; 5-HT3; sex steroids; androgen receptor; estrogen receptor; genetics; gene-gene interaction; social phobia; anxiety; premenstrual dysphoric disorder; depression; personality; autism; transsexualism; amygdala; emotional perception; life events;

   Sammanfattning : Background: The neurotransmitter serotonin has been related to mood and anxiety, and variation in genes that encode important members of the serotonergic system may hence affect mood- and anxiety-related traits. Sex steroids influence brain development, and variation in genes encoding androgen and estrogen receptors, or enzymes needed for sex steroid synthesis, may be of importance for both personality traits and risk for psychiatric disorders. LÄS MER

3. 2. The serotonin receptor type 3 in chronic and experimental human muscle pain

   Författare :Nikolaos Christidis; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :5-HT3 receptor; Granisetron; Human muscles; Muscle biopsy; Pain; Pressure pain threshold; Visual Analogue Scale; Randomized Controlled Double-blind Trial;

   Sammanfattning : The main aim of this thesis was to gain a better understanding of the influence of serotonin on chronic craniofacial muscle pain. The thesis comprised a basic science part and a human experimental part. LÄS MER

4. 3. Importance of serotonin-related candidate genes for human behaviour

   Författare :Jonas Melke; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serotonin; genetics; polymorphism; association study; personality; panic disorder; premenstrual dysphoria; serotonin receptor; serotonin transporter;

   Sammanfattning : Family and twin studies have been consistent in demonstrating that genetic factors are involved in the etiology of most major psychiatric disorders, as well as in various normal personality traits. Mostly due to the efficacy of serotonin-acting drugs, such as selective serotonin reuptake inhibitors (SSRI) and tricyclic antidepressants (TCA), the neurotransmitter serotonin has been implicated in a variety of common psychiatric disorders, including depression, a spectrum of anxiety disorders, and premenstrual dysphoria; moreover, some studies have suggested that also personality is influenced by serotonin. LÄS MER

5. 4. Direct and endothelium-linked serotonergic control of vascular tone in human uterine and umbilical arteries

   Författare :Caroline Karlsson; gynekologisk och prenatal ultraljudsdiagnostik Obstetrisk; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; andrology; gynaecology; Obstetrics; vascular smooth muscle; uterine artery human ; umbilical artery human ; serotonergic receptor; 5-HT; noradrenaline; endothelium; NPY; reproduction; sexuality; Obstetrik; gynekologi; andrologi; reproduktion; sexualitet;

   Sammanfattning : The serotonergic vascular control was investigated by in vitro pharmacology in the human uterine and umbilical arteries. The localisation of immunoreactive (IR) neuropeptide Y (NPY) and the influence of NPY on the adrenergic vascular effects in the human uterine artery were also studied. LÄS MER

7. 5. Involvement of lipid rafts in G protein-coupled monoamine receptor trafficking and signaling : a pharmacological approach

   Författare :Benita Sjögren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The present work focused on lipid raft-mediated modulation of signaling and trafficking of serotonin (5-HT) and dopamine receptors. The 5-HT system is one of the most complex neurotransmitter systems, with a wide distribution both in the CNS and in the periphery. LÄS MER