Sökning: "1054"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet 1054.

1. 1. Understanding Cancer Mutations by Genome Editing

   Författare :Muhammad Akhtar Ali; Tobias Associate Professor; Thierry Soussi; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genome editing; rAAV; ZBED6; DIP2C; KRAS; BRAF; colorectal cancer; tumor driver genes; cancer pathways;

   Sammanfattning : Mutational analyses of cancer genomes have identified novel candidate cancer genes with hitherto unknown function in cancer. To enable phenotyping of mutations in such genes, we have developed a scalable technology for gene knock-in and knock-out in human somatic cells based on recombination-mediated construct generation and a computational tool to design gene targeting constructs. LÄS MER

3. 2. Security and Efficiency Tradeoffs in Multicast Group Key Management

   Författare :Claudiu Duma; Nahid Shahmehri; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Key management; Multicast communication; Security-efficiency tradeoffs; Collusion resistance; Push-oriented approaches; Computer science; Datavetenskap;

   Sammanfattning : An ever-increasing number of Internet applications, such as content and software distribution, distance learning, multimedia streaming, teleconferencing, and collaborative workspaces, need efficient and secure multicast communication. However, efficiency and security are competing requirements and balancing them to meet the application needs is still an open issue. LÄS MER

4. 3. Innate and adaptive immunity in childhood celiac disease

   Författare :Göte Forsberg; Marie-Louise Hammarström; Riccardo Troncone; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunologi; Immunology;

   Sammanfattning : Celiac disease (CD) is an inflammatory small-bowel enteropathy caused by a permanent intolerance to wheat gluten and related proteins in rye and barley. Even though the disease originate from the small intestine the clinical symptoms varies in affected individuals and are often different in small children compared to adolescents and adults. LÄS MER

5. 4. Perceive those things which cannot be seen : A cognitive systems engineering perspective on requirements management

   Författare :Åsa Hedenskog; Rune Gustavsson; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Software tools; Usability requirements; Cognitive systems engineering; Systems engineering; Systemteknik;

   Sammanfattning : Non-functional requirements contribute to the overall quality of software, and should therefore be a part of any development effort. However, in practice they are often considered to be too difficult to handle. The purpose of this thesis is to gain understanding of where the nature and origin of these difficulties may lie. LÄS MER

7. 5. Dynamics of Discrete Curves with Applications to Protein Structure

   Författare :Shuangwei Hu; Antti J. Niemi; Maxim Zabzine; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Frenet equations; integrable model; folded proteins; discrete curves; Fysik; Physics; Physical Biology; Fysikalisk biologi;

   Sammanfattning : In order to perform a specific function, a protein needs to fold into the proper structure. Prediction the protein structure from its amino acid sequence has still been unsolved problem. The main focus of this thesis is to develop new approach on the protein structure modeling by means of differential geometry and integrable theory. LÄS MER