Sökning: "tryptophan depletion"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden tryptophan depletion.

  1. 1. Pteridine dependent hydroxylases as autoantigens in autoimmune polyendocrine syndrome type 1

    Författare :Olov Ekwall; Uppsala universitet; []
    Nyckelord :Medical sciences; APS I; alopecia; autoantigen; cDNA; malabsorption; phenylalanine hydroxylase; pteridine; tryptophan hydroxylase; tyrosine hydroxylase; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Autoimmune polyendocrine syndrome type I (APS) is a monogenous, recessively inherited disease characterised by endocrine and non-endocrine autoimmune manifestations. One fifth of APS I patients suffer from periodic intestinal dysfunction with varying degrees of malabsorbtion, steatorrhea and constipation. LÄS MER

  3. 2. Affective disorders in a stress-vulnerability perspective : a clinical, biological and psycho-social study

    Författare :Lars Johnson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Affective illness; bipolar illness; unipolar illness; twin study; cognitive dysfunction; age of onset; early parental loss; life events; tryptophan depletion; lithium; social support; personality; outcome.;

    Sammanfattning : Affective illness is a common, recurrent and often severe illness, which causes severe suffering to the patients and their families, friends and co-workers. Furthermore the costs for society are substantial. LÄS MER

  4. 3. Direct and indirect mechanisms for aryl hydrocarbon receptor activation mediated by 6-formylindolo[3,2-b]carbazole

    Författare :Emma Wincent; Ulf Rannug; Agneta Rannug; Christopher Bradfield; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi; toxikologisk genetik; Genetic Toxicology;

    Sammanfattning : The aryl hydrocarbon receptor (AhR) is mostly recognized for mediating the adverse effects of dioxins. In addition, endogenous activation of the AhR seems to have important biological functions.  Several studies have demonstrated an activation of the receptor when no exogenous ligand was added. LÄS MER

  5. 4. The role of microbial translocation and gut microbiota in HIV-1 infection

    Författare :Jan Vesterbacka; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : HIV-1 infection is characterized by persistent systemic inflammation and immune activation, even in patients receiving effective antiretroviral therapy (ART). Translocation of microbial compounds from a leaky gut to systemic circulation, so called microbial translocation (MT), is a major driver of the immune activation. LÄS MER

  7. 5. Multidisciplinary analysis of HIV-1 elite controllers

    Författare :Kajsa Noyan Gertler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic HIV-1 infection is characterized by progressive depletion of CD4+ T lymphocytes, persistent immune activation and ongoing viral replication, leading to a profound immunodeficiency state if left untreated with antiretroviral therapy. However, a small percentage of infected individuals are able to maintain durable control of HIV replication and stable CD4 counts, in the absence of antiretroviral treatment (ART). LÄS MER