Sökning: "transcription factor programming"

Hittade 3 avhandlingar innehållade orden transcription factor programming.

  1. 1. Generation of human astrocytes for disease modeling. A study based on stem cells, direct conversion and genome engineering to dissect the role of astrocytes in leukodystrophies

    Författare :Ella Quist; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Astrocytes; Stem Cells; transcription factor programming; direct conversion; genome engineering; CRISPR Cas9; leukodystrophy;

    Sammanfattning : Astrocytes are one of the major cell types in the central nervous system and are indispensable for brain development and function. The human brain and human astrocytes have unique structures and functions that are not present in other animal species. LÄS MER

  3. 2. Generation of cortical neurons through reprogramming technology

    Författare :Giedre Miskinyte; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cortex; Reprogramming; human ES cells; transcription factor programming; cortical projection neurons; Human adult cortical slices;

    Sammanfattning : The human cortex is affected by several debilitating acute and chronic neurodegenerative disorders such as stroke, traumatic brain injury, amyotrophic lateral sclerosis and Alzheimer’s disease, which target specific types of cortical neurons. Emerging evidence indicates that stem cells and reprogrammed cells can be used to generate human cortical neurons both for cell replacement by transplantation, and for disease modeling and drug screening. LÄS MER

  4. 3. Tissue- and site-specific effects of PPARγ activation and its role in chronic inflammation

    Författare :Sebastian Pott; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Developmental programming, metabolism, immune function and tissue homeostasis in multicellular organisms are regulated by a plethora of stimuli. Transcription factors (TFs) convert incoming signals to appropriate transcriptional responses of the genome. LÄS MER