Sökning: "thrombophilia"

Visar resultat 6 - 10 av 13 avhandlingar innehållade ordet thrombophilia.

  1. 6. Familial thrombophilia : Resistance to activated protein C and protein S deficiency

    Författare :Bengt Zöller; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Inherited resistance to activated protein C (APC-resistance) and protein S deficiency are associated with functional impairment of the protein C anticoagulant system, resulting in lifelong hypercoagulability andincreased risk of thrombosis. APC-resistance is the most common genetic cause of thrombosis being present in 20% to 60% of thrombosis patients. LÄS MER

  3. 7. Determination of the overall haemostasis potential and fibrin gel permeability : method development and application in research and in clinical materials

    Författare :Aleksandra Antovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Global haemostatic assays; overall haemostasis potential; hypercoagulation; hypocoagulation; thrombophilia; haemophilia; fibrin gel porosity; LMMH therapy; acetylsalicylic acid therapy;

    Sammanfattning : We have previously developed a laboratory method that may screen the Overall Haemostasis Potential (OHP) in plasma based on spectophotometric measurement of an area under the fibrin aggregation curve in citrated plasma samples to which tiny amounts of exogenous thrombin and tissue-plasminogen activator (t-PA) are added. When the fibrin aggregation curve is created, the fibrinogen originally present in plasma is gradually converted to fibrin by the generated thrombin. LÄS MER

  4. 8. VENOUS THROMBOEMBOLISM IN SOUTHERN SWEDEN EPIDEMIOLOGY AND RISK FACTORS

    Författare :Nazim Isma; Vaskulära sjukdomar - kliniska studier; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epidemiology; Venous thromboembolism VTE ; risk factors; factor V leiden FVL ; socioeconomic status SES ; upper extremety deep venous thrombosis UEDVT ; haemoglobin Hb ; low molecular weight heparin LMWH ; labour;

    Sammanfattning : Despite the fact that venous thromboembolism (VTE) is an important cause of morbidity and mortality there is still insufficient information on VTE risk factors and patient characteristics in the general population. Previously published incidences of VTE (deep venous thrombosis [DVT] and pulmonary embolism [PE]) vary from 71 to 192 per 100,000 individuals per year. LÄS MER

  5. 9. Thrombin generation in different cohorts : Evaluation of the haemostatic potential

    Författare :Roza Chaireti; Tomas Lindahl; Elvar Theodorsson; Sven Almer; Per Morten Sandset; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : The aim of this thesis is to evaluate thrombin generation in patients with thrombophilia (Paper I), in patients with venous thromboembolism (Paper II), in healthy women during the menstrual cycle (Paper III), in patients with liver disease (Paper IV) and in patients with mild deficiency of factor VII (Paper V).For this purpose, thrombin generation was measured in platelet poor plasma by the calibrated automated thrombogram (CAT®) assay. LÄS MER

  7. 10. Real-time analysis of blood coagulation and fibrinolysis : new rheological and optical sensing techniques for diagnosis of haemostatic disorders

    Författare :Kenny Hansson; Frank Brosstad; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The haemostatic system has a dual paradoxical function in the body. It should arrest bleeding whenever needed, but also keep the blood flowing in the circulatory system without any obstructing blood clots. The system is complex with maoy intertwined processes that interact to produce a fine-tuned regulation of the performance. LÄS MER