Sökning: "structural alteration"

Visar resultat 21 - 25 av 42 avhandlingar innehållade orden structural alteration.

  1. 21. Celluar and Molecular Mechanisms Underlying Regulation of Skeletal Muscle Contraction in Health and Disease

    Författare :Mingxin Li; Lars Larsson; Tomas Winkler; Alf Månsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Scaling; myosin heavy chain; in vitro motility assay; myopathy; Clinical neurophysiology; Klinisk neurofysiologi; Neuroscience; Neurovetenskap;

    Sammanfattning : Morphological changes, genetic modifications, and cell functional alterations are not always parallel. Therefore, assessment of skeletal muscle function is an integral part of the etiological approach. LÄS MER

  3. 22. Design, Synthesis and Biological Evaluation of Selective Nonpeptide AT2 Receptor Agonists and Antagonists

    Författare :Charlotta Wallinder; Anders Hallberg; Mathias Alterman; Anders Karlén; Elizabeth E. Sugg; Uppsala universitet; []
    Nyckelord :AT2 receptor agonist; AT2 receptor antagonist; Ang II peptidomimetics;

    Sammanfattning : The G protein-coupled receptors (GPCRs) are important targets in drug discovery. In several cases, the endogenous ligands that activate the GPCRs of pharmaceutical interest are peptides. LÄS MER

  4. 23. Hydrophobic interactions of serpins

    Författare :Sabina Janciauskiene; Enheten för kroniska inflammatoriska och degenerativa sjukdomar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteiner; enzymology; polymerization.; Proteins; conformational polymorphism; hydrophobic interaction; amyloid fibrils; Alzheimer`s peptide Ab; alpha-1-antichymotrypsin; C-terminal peptide; lithocholic acid; cholesterol; Key words: alpha-1-antitrypsin; bile acids; enzymologi;

    Sammanfattning : The proteins of the serpin family are primarily but not exclusively proteinase inhibitors, which share a common, similar structure. It is known that this structure undergoes major conformational changes upon cleavage in the serpin reactive site loop, and that these changes include rearrangements within the hydrophobic core of the molecule. LÄS MER

  5. 24. Crimean-Congo hemorragic fever virus : studies on molecular pathogenesis and host-cell interactions

    Författare :Helen Karlberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Crimean-Congo haemorrhagic fever (CCHF) disease in humans shows a spectrum of severity, from mild to acute. The pathogenesis of this and other viral haemorrhagic fevers (VHF) is associated with alteration of vascular barrier function and haemorrhage, but the specific underlying mechanism is unknown. LÄS MER

  7. 25. Multidrug-resistant Enterobacterales in Oman : molecular epidemiology and therapeutic insights

    Författare :Hissa M Al-Farsi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The spread of antibiotic resistance is a concerning issue causing limited treatment options for bacterial infections, particularly with Gram-negative bacteria. Surveillance and epidemiological studies help to determine the magnitude of the problem as well as to establish early measures to slow down the spread of resistance and consequently increase antibiotic lifespan. LÄS MER