Sökning: "plasmodium-falciparum malaria"

Visar resultat 1 - 5 av 117 avhandlingar innehållade orden plasmodium-falciparum malaria.

  1. 1. T-cell regulation of immune responses to the Plasmodium falciparum antigen Pf155/RESA

    Författare :Lalitha Kabilan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antigens; surface; immunology T-lymphocytes; Plasmodium falciparum;

    Sammanfattning : Plasmodium falciparum is the cause of the most severe malaria inhumans. Due to the rapid resurgence of malaria in many parts of theworld extensive efforts have been made during the last few years todefine several P.falciparum antigens for inclusion in a vaccine. LÄS MER

  3. 2. Uncovering the genetics underlying host-parasite interactions during Plasmodium falciparum malaria transmission

    Författare :Mubasher Mohammed; Johan Ankarklev; David Serre; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Malaria; Plasmodium falciparum; Genomics; single-cell RNA-seq; Parasite cell fate; Anopheles gambiae; ApiAP2 transcription factors; driver genes; computational biology; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : In eukaryotes, cellular differentiation is often orchestrated by programmed arrays of activation and repression of genes underlying the specific phenotypes of cell-types. To complete its life cycle, the single-celled Apicomplexan parasite Plasmodium falciparum, the most deadly of the human malaria parasites, must repeatedly differentiate and convert into unique cell types that can exploit niches within their human and mosquito hosts. LÄS MER

  4. 3. Human genetic factors involved in immunity to Plasmodium falciparum infection

    Författare :Manijeh Vafa Homann; Marita Troye-Blomberg; Marcel Hommel; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plasmodium falciparum; Malaria; Immunity; Ethnic groups; Mali; Senegal; Genetic factors; IL-4; IL-10; Polymorphism; MOI; RBC variants; Immunology; Immunologi; immunologi; Immunology;

    Sammanfattning : This study investigated the associations between IL-4 -590 C/T and IL-10 -1087 A/G polymorphisms and malariometric indexes in the Fulani and the Dogon ethnic groups living in sympatry in Mali and differing in susceptibility to malaria. The correlations between antibodies level and parasitological data as well as splenomegaly were assessed. LÄS MER

  5. 4. Antibody responses and Fc gamma receptor IIa polymorphism in relation to Plasmodium falciparum malaria

    Författare :Nnaemeka C. Iriemenam; Klavs Berzins; Marita Troye-Blomberg; Philippe Deloron; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; malaria; Plasmodium falciparum; blood-stage; antibodies; antigens; logistic models; risk factors; age factors; merozoites; IgG subclasses; Fc gamma RIIa; single nucleotide polymorphism; ethnicity; endemicity; disease susceptibility; Immunology; Immunologi; immunologi; Immunology;

    Sammanfattning : Immunity to asexual blood-stage of Plasmodium falciparum malaria is believed to be associated with protective antibodies of certain immunoglobulin classes and subclasses. This thesis addressed the importance of antibodies in relation to malaria infection and their effective interactions with Fc gamma receptor IIa (FcyRIIa) polymorphisms. LÄS MER

  7. 5. Design, production and characterization of synthetic immunogens : application on Plasmodium falciparum malaria antigens

    Författare :Anders Sjölander; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The development of synthetic subunit vaccines is presently one of the major strategies to construct vaccines against infectious diseases. Such vaccines are based on isolated and characterized immunogens and should include appropriate B- and T-cell epitopes. LÄS MER