Sökning: "model designs"

Visar resultat 1 - 5 av 509 avhandlingar innehållade orden model designs.

  1. 1. Intelligent System Designs : Data-driven Sensor Calibration & Smart Meter Privacy

    Författare :Yang You; Tobias J. Oechtering; Olga Fink; KTH; []
    Nyckelord :Electrical Engineering; Elektro- och systemteknik;

    Sammanfattning : Nowadays, the intelligent system has gained high popularity in successful implementation of real-time tasks due to its capability of providing efficient and powerful decision making in real applications. In this thesis, we aim for exploring and exploiting different concepts or methods to handle different tasks towards the intelligent system design. LÄS MER

  3. 2. A Traffic Simulation Modeling Framework for Rural Highways

    Författare :Andreas Tapani; Jan Lundgren; Karl-Lennart Bång; Linköpings universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Traffic; Micro; Simulation; Model; Overtaking; Speed; Headway; Rural road; Electronic driving aid; Mathematical model; Road: Traffic theory; Road: Traffic theory; Other technology;

    Sammanfattning : Models based on micro-simulation of traffic flows have proven to be useful tools in the study of various traffic systems. Today, there is a wealth of traffic microsimulation models developed for freeway and urban street networks. The road mileage is however in many countries dominated by rural highways. LÄS MER

  4. 3. Model-Based Optimization of Clinical Trial Designs

    Författare :Camille Vong; Mats O. Karlsson; Andrew C. Hooker; Lena E. Friberg; Marylore Chenel; Oliver Sander; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; likelihood ratio test; NONMEM; power; sample size; study design; proof-of-concept; dose-finding; population optimal design; LOQ; BQL data; neutropenia; docetaxel; myelosuppression; thrombocytopenia; MTD; Bayesian methods; 3 3 algorithm; dose escalation study; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. LÄS MER

  5. 4. Methods for handling model misspecification in pharmacometric model-based approaches for the analysis of longitudinal clinical trial data

    Författare :Estelle Chasseloup; Mats Karlsson; Andrew Hooker; Karl Brendel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; nonlinear mixed-effects models; misspecification; type I error; power; accuracy; placebo; individual model averaging; IMA; likelihood ratio test; LRT; model averaging; covariate selection; mixture models; visual predictive checks; VPC; avatars; digital twins; virtual individual; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Pharmacometrics model-based analyses proved to be increasingly useful in drug discovery and development. This usefulness was made evident by the formalisation of the model-integrated drug discovery and development framework (MID3). LÄS MER

  7. 5. Optimal adaptive designs and adaptive randomization techniques for clinical trials

    Författare :Yevgen Ryeznik; Warwick Tucker; Andrew Hooker; Franz König; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; optimal designs; optimal adaptive designs; randomization in clinical trials; restricted randomization; adaptive randomization; unequal cost; allocation ratio preserving randomization procedures; heterogeneous costs; multi-arm clinical trials; randomization-based inference; unequal allocation; Tillämpad matematik och statistik; Applied Mathematics and Statistics;

    Sammanfattning : In this Ph.D. thesis, we investigate how to optimize the design of clinical trials by constructing optimal adaptive designs, and how to implement the design by adaptive randomization. LÄS MER