Sökning: "lunds universitet medicin"

Visar resultat 1 - 5 av 1498 avhandlingar innehållade orden lunds universitet medicin.

  1. 1. The future of clinical trials for Alzheimer's disease. A blood-based biomarker perspective

    Författare :Nicholas Cullen; Klinisk minnesforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Biomarkers; Cognition; Amyloid; Tau; Neurodegeneration;

    Sammanfattning : Objectives: The primary objective was to investigate the utility of blood-basedbiomarkers of amyloid, tau, and neurodegeneration for (i) screening, (ii)enrichment, and (iii) tracking response to treatment in clinical trials of Alzheimer’sdisease.Methods: Longitudinal, participant-level data used in these studies was drawn fromthe Swedish BioFINDER study and the ADNI study. LÄS MER

  3. 2. Prevention of surgical site infections after lower extremity bypass procedures

    Författare :Francis Rezk; Vaskulära sjukdomar - kliniska studier; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic prophylaxis; surgical site infection; vascular surgery; lower extremity bypass; wound dehiscence; compliance; incisional negative pressure wound therapy; Hawthorne effect; healthcare professionals; observation; hygiene; adherence; patient experience; PICO-dressing;

    Sammanfattning : Abstract: Surgical site infections (SSIs) are a common cause of morbidity following open vascular surgery. Numerous randomized controlled trials (RCTs), along with systematic reviews and meta-analyses of RCTs, have been conducted to compare incisional negative pressure wound therapy (iNPWT) with standard wound dressings above sutured incisions in the inguinal region. LÄS MER

  4. 3. EVAR of AAA: Long term outcomes, disease progression and risk stratification

    Författare :Mohammed Abdulrasak; Vaskulära sjukdomar - kliniska studier; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; abdominal aortic aneurysm; Endovascular aortic repair; ilio-femoral calcium score; type Ia endoleak;

    Sammanfattning : BackgroundEndovasvular aortic repair (EVAR) is the most commonly utilised technique for the treatment of abdominal aorticaneurysms (AAA) in tertiary referral centers. Detailed long-term outcomes of this technique are relatively scarce,especially for patients presenting symptomatically with AAA. LÄS MER

  5. 4. Circulating biomarkers in patients with abdominal aortic aneurysm

    Författare :Despina Flondell-Sité; Vaskulära sjukdomar - kliniska studier; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; matrix metalloproteinases; biomarkers; risk factors; fibrinolysis; coagulation; inflammation; Abdominal aortic aneurysm; statin; interleukin 6.; APC-PCI complex; serpine-1; endothelin-1;

    Sammanfattning : Abdominal aortic aneurysm (AAA) develops in 3-6% of the population over 65 years and affects mainly men. AAA has a complex etiology involving inflammation, proteolysis, fibrinolysis and coagulation. LÄS MER

  7. 5. Reproductive Factors and Breast Cancer - Parity, Breastfeeding and Genetic Predisposition in Relation to Risk and Prognosis

    Författare :Salma Butt; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; subgroups; stage; survival; Breast cancer risk; parity; nulliparity; multiparity; breastfeeding; age at first birth; single nucleotide polymophisms;

    Sammanfattning : The aim of this thesis was to study reproductive factors and genetic polymorphisms in relation to breast cancer risk and survival. An important component of this was to investigate the risk of specific breast cancer subgroups. LÄS MER