Sökning: "kynurenic acid"

Visar resultat 1 - 5 av 29 avhandlingar innehållade orden kynurenic acid.

  1. 1. Endogenous kynurenic acid and schizophrenia : physiological and pharmacological aspects

    Författare :Lilly Schwieler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid is a glutamate receptor antagonist with a preferential action at the glycine/Dserine site of the N-methyl-D-aspartic acid (NMDA) receptor. The compound is a metabolite of tryptophan and is synthesized in astrocytes. LÄS MER

  3. 2. Glutamatergic mechanisms in schizophrenia : role of endogenous kynurenic acid

    Författare :Linda K Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid, a tryptohan metabolite synthesised in astrocytes, is an endogenous antagonist at glutamate receptors, in particular it blocks the glycine site of the (NMDA)-receptor, and at the a7* nicotinic receptor. The compound has been found to be elevated in the cerebrospinal fluid (CSF) as well as in the postmortem prefrontal cortex of patients with schizophrenia. LÄS MER

  4. 3. Influence of kynurenic acid on dopamine neurotransmission : implications for schizophrenia

    Författare :Alexandra Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid (KYNA) belongs to the kynurenines, a group of metabolically related compounds derived from the amino acid tryptophan. It is an antagonist of glutamate- and α7 nicotinic acetylcholine (α7nACh) receptors. Increased levels of KYNA have been observed in the cerebrospinal fluid and postmortem brains of patients with schizophrenia. LÄS MER

  5. 4. Kynurenic acid in psychiatric disorders : studies on the mechanisms of action

    Författare :Klas Linderholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid, a metabolite of tryptophan along the kynurenine pathway, is an endogenous antagonist at NMDA- and α7* nicotinic acetylcholine- (α7*nACh) receptors. Previous studies have shown that elevated levels of endogenous kynurenic acid are associated with an increased firing of midbrain dopamine neurons as well as a reduced prepulse inhibition (PPI), a behavioral model for sensorimotor gating. LÄS MER

  7. 5. The pathophysiological roles of kynurenic acid and cytokines in psychiatric illness

    Författare :Sara Olsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid is an astrocyte-derived tryptophan metabolite and a marker of neuroinflammation that antagonizes N-metyl-D-aspartate (NMDA) and α7 nicotinic acetylcholine receptors in the brain. Increased levels have been found in the cerebrospinal (CSF) and brains of patients with schizophrenia and experimental studies have shown that kynurenic acid bi-directionally influences dopaminergic neurotransmission. LÄS MER