Sökning: "gastrointestinal stromal tumors"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden gastrointestinal stromal tumors.

  1. 1. Gastrointestinal stromal tumors. Pathogenetic mechanisms, phenotypic characterization and prognosis

    Författare :Johanna Andersson; Göteborgs universitet; []
    Nyckelord :Gastrointestinal stromal tumor GIST ; neurofibromatosis type I NF1 ; mutation; prognosis; denaturating high performance liquid chromatography dHPLC ; sequencing; KIT; PDGFRA; NF1;

    Sammanfattning : Gastrointestinal stromal tumor (GIST), the most common non-epithelial neoplasm of the gastrointestinal tract, has historically been problematic both conceptually and clinically. Recently, GIST has been shown to share phenotypic features with the interstitial cells of Cajal (ICC), including the almost uniform expression of the tyrosine kinase receptor KIT. LÄS MER

  3. 2. Novel aspects of the molecular biology of gastrointestinal stromal tumors

    Författare :Erik Berglund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor in the gastrointestinal tract (GI). Historically, these tumors were commonly mistaken for myogenic and neurogenic masses, and then eventually came to be recognized as a distinct type of soft-tissue sarcoma through ultrastructural findings and specific immunomarkers. LÄS MER

  4. 3. MicroRNA and energy metabolism in gastrointestinal tumors

    Författare :Wen-Kuan Huang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : MicroRNAs (miRNAs) contribute to cancer development and drug resistance via cellular biological processes, including metabolic pathways. Energy metabolism plays a significant role to maintain tumor proliferation in gastrointestinal (GI) cancers. However, the roles of miRNAs and energy metabolism in GI cancers are not fully understood. LÄS MER

  5. 4. Epidemiological and experimental studies on sarcoma with focus on gastrointestinal stromal tumors

    Författare :Fredrik Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Sarcoma is the common denominator for malignant tumors of mesenchymal origin. Sarcomas encompass almost 100 diagnoses with different histology, molecular features and natural history, and may present in any part of the body. The most common sarcoma in the abdomen is the gastrointestinal stromal tumor (GIST). LÄS MER

  7. 5. Translational investigations of novel and current antitumoral therapies in gastrointestinal stromal tumors

    Författare :Robin Fröbom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gastrointestinal stromal tumor (GIST) is the most common human sarcoma. Its incidence is around 10-15 per million person-years, translating into 150 new cases each year in Sweden. LÄS MER