Sökning: "conserved synteny"

Visar resultat 6 - 10 av 10 avhandlingar innehållade orden conserved synteny.

1. 6. Hypoxia inducible factor 1alpha : molecular mechanisms of regulation

   Författare :William J Wilson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Hypoxia-Inducible Factor 1alpha (HIF-1alpha) is an important protein in the homeostatic control of genes in response to low oxygen, or hypoxia. It is thus also a key factor in the regulation of angiogenesis in response to hypoxia, including induction of vascular endothelial growth factor (VEGF) gene expression. LÄS MER

3. 7. Gene complexes and regulatory domains in metazoan genomes

   Författare :Pär Engström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Despite the recent massive increases in genome and transcript sequence data, including wholegenome sequences for humans and many other metazoans, our understanding of the content of these sequences is far from complete. This thesis is about making use of metazoan sequence data to detect functional genetic elements on a genome-wide scale and examine the distribution of those elements on chromosomes. LÄS MER

4. 8. Methods and Applications in Comparative Bacterial Genomics

   Författare :Hans-Henrik Fuxelius; Siv Andersson; Björn Andersson; Uppsala universitet; []
   Nyckelord :Biology; Biologi;

   Sammanfattning : Comparative studies of bacterial genomes, now counting in the hundreds, generate massive amounts of information. In order to support a systematic and efficient approach to genomic analyses, a database driven system with graphic visualization of genomic properties was developed - GenComp. LÄS MER

5. 9. Molecular evolution of the neuropeptide Y receptor family : Insights from mammals and fish

   Författare :Amanda Wraith; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

   Sammanfattning : Most genes in the genomes of vertebrates form families with multiple members that are more or less closely related. This thesis concerns investigations of the neuropeptide Y (NPY) family of peptides and the family of receptors to which these peptides bind, the NPY receptors. LÄS MER

7. 10. Mapping the genome and characterization of an acetyltransferase of Trypanosoma cruzi

   Författare :Stephen O Ochaya; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Trypanosoma cruzi; Chagas´disease; karyotyping; genomic; acetyltransferase;

   Sammanfattning : Trypanosoma cruzi (T.cruzi) is a flagellate protozoan parasite that causes Chagas' disease and is most common in Latin American countries. The disease currently infects over 13 million persons and about 100 million more are at risk. Despite basic research for many years, there is neither a vaccine nor useful drugs available to combat the disease. LÄS MER