Sökning: "chronic myelomonocytic leukemia"
Hittade 2 avhandlingar innehållade orden chronic myelomonocytic leukemia.
1. Immunotherapy and immunosuppression in myeloid leukemia
Sammanfattning : Acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) are potentially life-threatening blood cancers characterized by the expansion of malignant myeloid cells in bone marrow and other organs. This thesis aimed at contributing to the understanding of the role of natural killer (NK) cells in AML and CMML with focus on the potential impact of the immunosuppression exerted by reactive oxygen species (ROS) formed by the myeloid cell NOX2 enzyme. LÄS MER
2. Paracrine and autocrine functions of PDGF in malignant disease
Sammanfattning : Growth factors and their receptors are frequently activated by mutations in human cancer. Platelet-derived growth factor (PDGF)-B and its tyrosine kinase receptor, the PDGF β-receptor, have been implicated in autocrine transformation as well as paracrine stimulation of tumor growth. LÄS MER