Sökning: "Serotonin antagonist"

Visar resultat 16 - 20 av 63 avhandlingar innehållade orden Serotonin antagonist.

  1. 16. The serotonin receptor type 3 in chronic and experimental human muscle pain

    Författare :Nikolaos Christidis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :5-HT3 receptor; Granisetron; Human muscles; Muscle biopsy; Pain; Pressure pain threshold; Visual Analogue Scale; Randomized Controlled Double-blind Trial;

    Sammanfattning : The main aim of this thesis was to gain a better understanding of the influence of serotonin on chronic craniofacial muscle pain. The thesis comprised a basic science part and a human experimental part. LÄS MER

  3. 17. Novel insights into the role of serotonin in control of β-cell fuction

    Författare :Hedvig Bennet; Celiaki och diabetes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Inadequate insulin secretion is a central component in the development of Diabetes Mellitus, resulting from reduced pancreatic β-cell mass, as well as diminished β-cell function. Islet produced 5-hydroxy tryptamine (5-HT) is suggested to regulate insulin secretion and β-cell mass in rodents during pregnancy and in metabolically challenged states. LÄS MER

  4. 18. Significance of serotonin for pain, allodynia, and hyperalgesia in the human masseter muscle

    Författare :Malin Ernberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Anxiety; Double-Blind Method; 5-Hydroxytryptamine; Fibromyalgia; Hyperalgesia; Masseter muscle; Microdialysis; Pain threshold; Visual Analogue Pain Scale;

    Sammanfattning : The main aim of this thesis was to investigate the hypothesis that serotonin (5-HT) is involved in the pathophysiology of human chronic muscle pain. The thesis comprises a clinical and a human experimental part. LÄS MER

  5. 19. Assessment of dopamine and serotonin release in the non-human primate brain using PET

    Författare :Sjoerd J. Finnema; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The molecular imaging technique positron emission tomography (PET) allows for non-invasive examination of biochemical markers in the living brain. For over three decades PET studies have provided important insight into the relationship of monoaminergic neurotransmitter systems to brain functioning and psychiatric disorders. LÄS MER

  7. 20. Development of radioligands for the serotonergic neurotransmission system for use in positron emission tomography

    Författare :Johan Sandell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PET; Radioligand; Brain; 5-HT1A receptor; serotonin transporter;

    Sammanfattning : The serotonergic system is implicated in several neuropsychiatric disorders, such as depression, anxiety and schizophrenia. Several hypotheses on the pathophysiology of these disorders are based on the pharmacology of serotonergic drugs. Selective serotonin reuptake inhibitors (SSRIs) are widely used for the treatment of depression and anxiety. LÄS MER