Sökning: "Regional perfusion"

Visar resultat 1 - 5 av 68 avhandlingar innehållade orden Regional perfusion.

  1. 1. Monitoring of Splanchnic Regional Perfusion : An Experimental Study of New Application and Validation

    Författare :Itaru Koga; Lennart Christiansson; Lars Wiklund; Björn Biber; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaesthesiology and intensive care; Splanchnic circulation; Regional ischemia; Hepatic artery buffer response; Air tonometry; Intraperitoneal; Reflectance pulse oximetry; Hepatic venous oxygen saturation; Lactate; PCO2 gap; Anestesiologi och intensivvård; Anaesthetics and intensive care; Anestesiologi och intensivvård;

    Sammanfattning : Systemic infection, major surgery, trauma and many other causes can lead to impaired organ function. Compensated shock is not detected by global hemodynamic and oxygen measurements, as they take no account for regional variations. LÄS MER

  3. 2. Quantitative Tracer Based MRI Perfusion : Potentials and Limitations

    Författare :Arvid Morell; Atle Bjørnerud; Håkan Ahlström; Linda Knutsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MRI; Perfusion; Contrast agent; Relaxivity; Radiology; Radiologi;

    Sammanfattning : Tracer based MRI perfusion measurements is a clinically useful tool to assess regional distributions of tissue blood flow and volume. The method may be based on any of the three relaxation mechanisms T1, T1 and T2*, the latter denoted DSC-MRI being the most common. LÄS MER

  4. 3. Immunological effects of isolated regional perfusion in malignant melanoma

    Författare :Junko Johansson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Isolated regional perfusion; ILP; IHP; Melphalan; Immunogenic cell death; T cells; Monocytes; ISG;

    Sammanfattning : Malignant melanoma patients with metastatic disease confined to the limbs or liver may be treated with hyperthermic isolated regional perfusion with a chemotherapeutic agent, most commonly melphalan. This procedure enables much higher tissue concentrations of the chemotherapeutic agent compared with systemic administration. LÄS MER

  5. 4. Optimisation and Validation of Dynamic Susceptibility Contrast MRI Perfusion Measurements

    Författare :Linda Knutsson; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nukleärmedicin; radiobiologi; Nuclear medicine; radiobiology; radiologi; tomografi; medicinsk instrumentering; tomography; medical instrumentation; Clinical physics; cerebral blood volume; mean transit time; cerebral blood flow; perfusion; dynamic susceptibility contrast MRI arterial input function; Klinisk fysiologi; radiology;

    Sammanfattning : The studies presented in this thesis concern the optimisation and evaluation of the dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) technique for the assessment of perfusion-related parameters of the brain, such as cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT). Several methodological factors influence these measurements, for example, contrast-agent administration, arterial input function (AIF) registration, choice of deconvolution algorithm and the choice of pulse-sequence parameters. LÄS MER

  7. 5. Isolated regional perfusion for metastases of malignant melanoma - Clinical and experimental studies

    Författare :Roger Olofsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Malignant melanoma; Uveal melanoma; Isolated limb perfusion; Isolated hepatic perfusion; Immunology; Exosomes;

    Sammanfattning : Background: Isolated regional perfusion is a treatment option mainly for localized metastatic disease. The principle idea is to surgically isolate a region of the body and connect the circulation to a heart-lung machine. A high concentration of a chemotherapeutic agent is then delivered to the tumour, while systemic toxicity is avoided. LÄS MER