Sökning: "Raymond Josephsson"

Hittade 2 avhandlingar innehållade orden Raymond Josephsson.

1. 1. Radiolabelled Oligonucleotides for Evaluation of in vivo Hybridisation Utilising PET Methodology

   Författare :Gábor Lendvai; Mats Bergström; Sergio Estrada; Barbro Eriksson; Raymond Josephsson; Bertrand Tavitian; Uppsala universitet; []
   Nyckelord :Molecular medicine; Gene expression; Antisense oligonucleotides; Positron emission tomography; In vivo hybridisation; In vivo biodistribution; Chromogranin-A; 68Ga; RT-PCR; Scavenger receptors; Molekylärmedicin;

   Sammanfattning : Antisense oligonucleotides (ODN) may interfere in gene expression on the basis of hybridising to its complementary messenger RNA (mRNA) sequence in the cell thereby preventing the synthesis of the peptide. Therefore, these ODNs may be potential drugs to treat human diseases by “knocking down” the expression of responsible genes or correcting the maturation process of mRNA in the field called antisense therapy. LÄS MER

3. 2. Multicellular Tumour Spheroids in a Translational PET Imaging Strategy

   Författare :Azita Monazzam; Mats Bergström; Carl Blomqvist; Jörgen Carlsson; Raymond Josephsson; Eric O Aboagye; Uppsala universitet; []
   Nyckelord :Oncology; Positron Emission Tomography; Multicellular Tumour Spheroid; Translational Research; Onkologi;

   Sammanfattning : Positron Emission Tomography (PET) has gained an important roll in clinical for diagnosis, staging and prognosis of a range of cancer types. Utilization of PET for monitoring and evaluation of cancer treatment is an attractive but almost new concept. The proper choice of PET-tracer as a biomarker for treatment follow-up is crucial. LÄS MER