Sökning: "Raloxifene"

Visar resultat 6 - 10 av 12 avhandlingar innehållade ordet Raloxifene.

  1. 6. First-pass Intestinal Metabolism of Drugs : Experiences from in vitro, in vivo and simulation studies

    Författare :Helena Anna Thörn; Hans Lennernäs; Paul Alfred Dickinson; Brian Houston; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; metabolism; CYP3A4; CYP2C9; CYP2D6; UGT; glucuronidation; physiologically based pharmacokinetic model; modelling; Biopharmaceutics; Biofarmaci;

    Sammanfattning : The bioavailability of a drug can be described as the fraction of an orally administered dose that reaches the systemic circulation and is often limited by first-pass metabolism in the gut and the liver. It is important to have knowledge about these processes since the systemic blood drug concentration is tightly connected to the effect of the drug. LÄS MER

  3. 7. Health economics of osteoporosis

    Författare :Fredrik Borgström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Economic evaluation; cost-effectiveness; osteoporosis; fracture related costs; quality of life;

    Sammanfattning : Health economics is concerned about how the scarce resources should most efficiently be allocated to maximise the health outcomes. Health economic evaluation is a method for assessing costs and benefits of alternative treatment strategies for allocating resources to assist decisions aiming at improving efficiency. LÄS MER

  4. 8. Modulation of estrogen receptors alpha and beta. Effects on the immune system

    Författare :Malin Erlandsson; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : Estrogen affects the development and function of the immune system. Gonadectomized mice treated with estrogen display suppressed T and B lymphopoiesis and inhibited T cell and granulocyte dependent inflammation, while mature B cells are stimulated to produce more immunoglobulins. LÄS MER

  5. 9. Arthritis and immune-mediated bone loss - role of estrogen signalling pathways

    Författare :Cecilia Engdahl; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Arthritis; Bone; Estrogen;

    Sammanfattning : Objective: Rheumatoid arthritis (RA) is associated with immune-mediated bone loss and thereby increased risk for fractures. Estrogen and selective estrogen receptor modulators (SERMs) ameliorate not only the incidence and progression of experimental RA but also the immune-mediated bone loss. LÄS MER

  7. 10. The role of estrogen in growth plate chondrogenesis

    Författare :Ola Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Overall body proportion is determined by the size of the skeleton, which in turn is determined by the rate and duration of longitudinal bone growth. Longitudinal bone growth occurs at the growth plate and is regulated by a variety of hormones and growth factors. LÄS MER