Sökning: "PTCH"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet PTCH.

  1. 1. Studies on basal cell carcinoma with emphasis on the role of the human homologue of the Drosophila patched gene

    Författare :Anne Birgitte Undén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Basal cell carcinoma BCC ; carcinogenesis; in situ hybridization; linkageanalysis; gene; mutation; PCR; p53; PTCH; SHH; skin; SSCP; stromelysin 3 ST3 ; trichoepithelioma TE ; UVR.;

    Sammanfattning : Basal cell cancer (BCC) is the most common cancer in the Western world. Although BCCs hardly ever metastasize, invasive growth may cause considerable local tissue destruction. Ultraviolet radiation (WR) is presumed to be the predominant environmental factor. LÄS MER

  3. 2. p53 Alterations in Human Skin : A Molecular Study Based on Morphology

    Författare :Ling Gao; Christer Bush Bush; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; p53; skin; mutation; carcinogenesis; microdissection; UV; Basal cell cancer BCC ; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Mutation of the p53 gene appears to be an early event in skin cancer development. The present study is based on morphology and represents a cellular and genetic investigation of p53 alterations in normal human skin and basal cell cancer. LÄS MER

  4. 3. Predictive and prognostic factors in cervical carcinomas treated with (chemo-) radiotherapy

    Författare :Louise Bohr Mordhorst; Bengt Sorbe; Preben Kjölhede; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cervical carcinoma; radio-chemotherapy; biomarkers; predictive factors; prognostic factors; multiprotein analysis; Hedgehog pathway; Wnt β-catenin pathway; Surgery; Kirurgi;

    Sammanfattning : A series of 131 women with cervical carcinoma FIGO stage I-IV were treated with external radiotherapy and intracavitary brachytherapy. In 47 patients (36%) concomitant chemotherapy was given. One hundred and twenty-one tumors (92%) achieved complete remission. Addition of chemotherapy increased primary cure rate to 98%. LÄS MER

  5. 4. Cancer Genomics - Molecular Analysis of Epithelial Cells

    Författare :Anna C. Gustafsson; KTH; []
    Nyckelord :DNA microarray; Pyrosequencing;

    Sammanfattning : Cancer is a disease involving multiple causal andsymptomatic genetic changes, collectively reflecting theselective pressures that occur during tumor development.Epithelial cancers are by far the most common type of cancerworldwide and investigation of the alterations associated withepithelial carcinogenesis will ultimately lead to improvementsin diagnosis, prognosis, prevention and treatment of thedisease. LÄS MER

  7. 5. Repressing the hedgehog signalling pathway

    Författare :Jessica Svärd; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Hedgehog (Hh) signalling pathway is essential for metazoan development and aberrant activation of the pathway is found in tumours. Mutations in Hh pathway components are found in several tumour types, including basal cell carcinoma (BCC) and medulloblastoma (MB). LÄS MER