Sökning: "NATURAL SCIENCES Chemistry Organic chemistry Bioorganic chemistry"

Visar resultat 16 - 20 av 28 avhandlingar innehållade orden NATURAL SCIENCES Chemistry Organic chemistry Bioorganic chemistry.

  1. 16. Conformationally Constrained Nucleic Acids as Potential RNA Targeting Therapeutics

    Författare :Zhou Chuanzheng; Jyoti Chattopadhyaya; Serge Beaucage; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; Bioorganisk kemi; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi;

    Sammanfattning : .... LÄS MER

  3. 17. Efficient Carbohydrate Synthesis By Intra- and Supramolecular Control

    Författare :Hai Dong; Olof Ramström; Ulf Nilsson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carbohydrate Chemistry; Supramolecular Control; Ambident Reactivity; Bioorganic chemistry; Bioorganisk kemi;

    Sammanfattning : The Lattrell-Dax method of nitrite-mediated substitution of carbohydrate triflates is an efficient method to generate structures of inverse configuration. In this study, the effects of the neighboring group on the Lattrell-Dax inversion were explored. LÄS MER

  4. 18. Stereoelectronic effects in nucleosides and nucleotides

    Författare :Christophe Thibaudeau; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; Bioorganisk kemi; Bioorganic chemistry; Bioorganisk kemi; bioorganisk kemi; Biorganic Chemistry;

    Sammanfattning : This thesis is based on 12 original publications from 1994-98. Intramolecular stereoelectronicforces (anomeric and gauche effects), beside intermolecular forces such as hydrogen bonding,base stacking, electrostatics and hydration, have been found to be responsible for the localstructural changes of DNA and RNA and their components. LÄS MER

  5. 19. Natural Products from Cameroonian Medicinal Plants

    Författare :Apollinaire Tsopmo; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Växtbiokemi; Plant biochemistry; antiplasmodial.; antitrypanosomal; diarylheptanoids; terpenoids; flavonoids; aframodial; Aframomum; Reneilmia cincinnata; Dorstenia; Euphorbia; Lepidobotrys staudtii; Pentadiplandra brazzeanea; Vernonia guineensis; Natural products; Myrica arborea;

    Sammanfattning : Natural product chemistry is a main research area in Cameroon, as well as for the division of Bioorganic Chemistry at Lund Institute of Technology. A review of the results obtained recently with Cameroonian medicinal plants shows that a large number of compounds, many with complex structures, have been isolated and characterised, and the work presented in this thesis is part of this effort. LÄS MER

  7. 20. Conformationally Constrained Oligonucleotides for RNA Targeting

    Författare :Qing Li; Jyoti Chattopadhyaya; Li-He Zhang; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; conformationally constrained nucleoside; antisense oligonucleotide; RNA affinity; nuclease stability; RNase H; RNA degradation; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi;

    Sammanfattning : A short oligonucleotide sequence as in a single-stranded antisense oligo nucleotides (AON) or in double-stranded small interfering RNAs (siRNA) can modulate the gene expression by targeting against the cellular mRNA, which can be potentially exploited for therapeutic purposes in the treatment of different diseases. In order to improve the efficacy of oligonucleotide-based drugs, the problem of target affinity, nuclease stability and delivery needs to be addressed. LÄS MER