Sökning: "Glucuronide Production"

Hittade 3 avhandlingar innehållade orden Glucuronide Production.

  1. 1. Drug Metabolites Formed by Cunninghamella Fungi : Mass Spectrometric Characterization and Production for use in Doping Control

    Författare :Axel Rydevik; Mikael Hedeland; Ulf Bondesson; David Cowan; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cunninghamella blakesleeana; Cunninghamella elegans; Doping Control; Drug Metabolites; Glucuronide Production; Mass Spectrometry; Reactive Metabolites; Reference Material; Structural Characterization; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : This thesis describes the in vitro production of drug metabolites using fungi of the Cunninghamella species. The metabolites were characterized with mainly liquid chromatography-mass spectrometry using ion-trap and quadrupole-time-of-flight instruments. A fungal in vitro model has several advantages e.g. LÄS MER

  3. 2. Genetics of androgen disposition : implications for doping tests

    Författare :Jenny Jakobsson Schulze; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Anabolic androgenic steroids (AAS) are derivatives of testosterone. Doping with AAS is a severe challenge to the vision, moral and ethics in sports and has also become an increasing problem in society. Testosterone abuse is conventionally assessed by the urinary testosterone glucuronide/ epitestosterone glucuronide (T/E) ratio, levels above 4. LÄS MER

  4. 3. The role of the prostate in androgen metabolism

    Författare :Mats Olsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The androgenic steroid hormones are essential for the physiological development of the prostate gland and are also implicated in pathological processes such as benign prostatic hyperplasia and prostate cancer. The systemic effect of endocrine activity in the prostate gland has so far been considered of minor importance. LÄS MER