Sökning: "GR interacting proteins"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden GR interacting proteins.

1. 1. Studies of glucocorticoid receptor interacting proteins

   Författare :Christina Widén; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The glucocorticoid receptor (GR) functions as a ligand dependent transcription factor. Nonliganded GR resides mainly in the cytoplasm bound to a complex containing heat shock proteins (hsp). LÄS MER

3. 2. Modulation of nuclear receptor function by interacting proteins

   Författare :Waffa Osman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Nuclear receptors are a family of transcription factors involved in many biological processes. They represent key potentials as therapeutic targets for several clinical conditions such as diabetes, obesity, cardiovascular disease and cancer, because their activity is modulated by small molecules. LÄS MER

4. 3. Glucocorticoid receptor function : interactions, mutants and ligand responses

   Författare :Erik Hedman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Glucocorticoid receptor; glucocorticoids; cross-talk; GR interacting proteins; Flt3; mass spectrometry; 2D gel electrophoresis;

   Sammanfattning : The protein that is investigated in this thesis is the glucocorticoid receptor (GR), which belongs to the nuclear hormone receptor superfamily of ligand activated transcription factors. The nuclear receptors share three conserved structural domains, the N-terminal transactivating domain, the central DNA-binding domain and the C-terminal ligand-binding domain. LÄS MER

5. 4. Transcription factors involved in negative and positive gene regulation by glucocorticoids

   Författare :Nanthakumar Subramaniam; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Steroid hormones, including glucocorticoids (GCs), control a wide variety of developmental and physiological responses in higher eukaryotic organisms. They pass through the plasma membrane and bind to specific receptor proteins inside the cell. LÄS MER

7. 5. Remodelling of the cellular environment in Epstein-Barr virus infection

   Författare :Simone Callegari; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : For successful infection viruses modify the host cell environment by transcriptional, posttranscriptional or post-translational regulation of cellular signaling pathways. In the work described in this thesis bioinformatics analysis coupled with biochemical validations were used to dissect critical features of these viral strategies in the context of infection by Epstein–Barr virus (EBV), a human herpesvirus associated with lymphoid and epithelial cell tumors. LÄS MER