Sökning: "First Episode Psychosis"

Visar resultat 6 - 10 av 15 avhandlingar innehållade orden First Episode Psychosis.

  1. 6. Immunological Changes and Brain Function over a Psychotic-Depressive Spectrum

    Författare :Elisabeth R. Paul; Laura Korhonen; J. Paul Hamilton; Mats Lekander; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Psychotic and depressive disorders are severe psychiatric disorders that contribute significantly to the global burden of disease. They are distinct disorders with different symptom profiles according to both the Diagnostic and Statistical Manual and the International Classification of Diseases. LÄS MER

  3. 7. Long-term Outcome, Suicidal behaviour, Quality of Life and Expressed Emotion in Adolescent Onset Psychotic Disorders

    Författare :Håkan Jarbin; Helmut Remschmidt; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Child and adolescent psychiatry; schizophrenia; affective disorder; bipolar disorder; outcome; suicide; quality of life; expressed emotion; Barn- och ungdomspsykiatri; Child and adolescent psychiatry; Barn- och ungdomspsykiatri; barn- och ungdomspsykiatri; Child and Youth Psychiatry;

    Sammanfattning : This study investigated a consecutive cohort of 88 youngsters with onset of a psychotic disorder at age 15.7 (sd 1.5) years and followed-up 10.6 (sd 3. LÄS MER

  4. 8. Brain immune mechanisms in schizophrenia : experimental and clinical characterization

    Författare :Maximilian Tufvesson Alm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The role of inflammation has become increasingly evident in the pathophysiology of schizophrenia and thought to one of the major causes of the symptoms. Interestingly, immune activation has been linked to the kynurenine pathway of tryptophan degradation, which produces an array of neuroactive metabolites. LÄS MER

  5. 9. Deciphering the interplay between peripheral and central cytokine- and kynurenine pathways : importance for the pathophysiology of schizophrenia

    Författare :Funda Orhan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Growing evidence suggests a role of low-grade inflammation in the pathophysiology of schizophrenia, giving rise to a dysregulation in neurons containing dopamine and glutamate as well as γ-aminobutyric acid (GABA). In this thesis, a role of peripheral and brain-immune signaling molecules, as well as brain neurotransmitters, was investigated in a wellcharacterized cohort of first-episode psychosis (FEP) patients. LÄS MER

  7. 10. Complement mediated synapse elimination in schizophrenia

    Författare :Jessica Florentina Gracias Lekander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Schizophrenia (SCZ) is a devastating psychiatric disorder with a typically age of onset in late adolescence. The heritability is estimated to be in between 60-80% and large-scale genome-wide studies have revealed a prominent polygenic component to SCZ risk and identified more than three-hundred common risk variants. LÄS MER