Sökning: "CAG polymorphism"

Visar resultat 6 - 8 av 8 avhandlingar innehållade orden CAG polymorphism.

1. 6. Molecular genetic studies on Huntington disease

   Författare :Elisabeth Almqvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Huntington disease; PCR; predictive testing;

   Sammanfattning : Huntington disease (HD) is an autosomal dominant neurodegenerative disorder associated with an expanded trinucleotide repeat (CAG). Prior to the gene identification in 1993, linkage analysis was used for predictive testing for at-risk individuals. LÄS MER

3. 7. Tracking functional changes in the cancer genome : a molecular genetic analysis of renal and prostatic carcinomas using PCR based techniques by a candidate chromosome and candidate gene approach

   Författare :Chunde Li; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Renal cell carcinoma; Prostatic Carcinoma; Molecular Genetics;

   Sammanfattning : Renal cell carcinoma (RCC) is the most common malignancy occurring in the adult kidney. Prostatic carcinoma is the most common male malignancy in most Western countries. Several environmental factors have been suggested to contributed to the tumor genesis but the involvement of genetic factors is also recognized. LÄS MER

4. 8. Molecular Genetic Studies on Prostate and Penile Cancer

   Författare :Patiyan Andersson; Peter Söderkvist; Mattias Höglund; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; IRS1; penile cancer; hTERT; FHIT; PIK3CA; HRAS; KRAS; NRAS; BRAF; Oncology; Onkologi;

   Sammanfattning : This thesis is comprised of two parts. In the first part we study the influence of four frequently disputed genes on the susceptibility for developing prostate cancer, and in the second part we attempt to establish a basic understanding of the molecular genetic events in penile cancer. LÄS MER