Sökning: "Animal models"

Visar resultat 16 - 20 av 763 avhandlingar innehållade orden Animal models.

1. 16. Gene expression profiling in animal models of alcoholism

   Författare :Christina Arlinde; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Alcoholism; gene expression; microarray; animal model; rat; brain;

   Sammanfattning : Genetic and environmental factors in alcoholism interact at the level of the transcriptome to encode the phenotypic traits of this complex clinical syndrome. Because of this, the prospect of simultaneous, genome wide, high-throughput analysis of gene expression in key brain areas potentially offers a novel strategy to identify new molecular treatment targets in this disease. LÄS MER

3. 17. Experimental porcine models of retinal ischemia

   Författare :Håkan Morén; Lund Oftalmologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retinal ischemia; animal model; multifocal electroretinography; intraarterial coiling; retinal vasculature;

   Sammanfattning : Retinal ischaemia resulting from e.g. diabetes, vein thrombosis or arterial occlusion, is one of the major causes of visual impairment and blindness. Although new methods of treatment are being developed, there is still a need for more effective pharmacological forms of treatment. LÄS MER

4. 18. Gastric and enteric Helicobacter species in animal models and in the human colon

   Författare :Erik Sturegård; Malmö Klinisk mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mycology; Mikrobiologi; bakteriologi; IL-10; Microbiology; bacteriology; virology; virologi; mykologi; hepatitis; colitis; IBD; inflammatory bowel disease; gastritis; animal model; mouse; guinea pig; Helicobacter ganmani; Helicobacter; Helicobacter pylori;

   Sammanfattning : The Gram-negative genus of Helicobacter consists of many bacterial species that colonize a wide range of animal hosts. The genus can be divided into gastric species that colonize the stomach, and enteric species that preferentially colonize the colon and biliary tree of various animal hosts. LÄS MER

5. 19. Cognitive function studied in animal models of schizophrenia

   Författare :Erik Pålsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; phencyclidine; nitric oxide; prepulse inhibition; latent; nitric oxide; prepulse inhibition; latent inhibition; habituation; NMDA receptor; rat; mouse; cognition; schizophrenia;

   Sammanfattning : Cognitive dysfunction is considered a core deficit of schizophrenia, which currently lacks effective pharmacological treatment. In order to identify novel and more effective drug treatments, translational experimental animal models of cognitive dysfunction are required. Schizophrenia-like symptoms can be induced in humans by phencyclidine (PCP). LÄS MER

7. 20. Genetic analysis of autoimmune diseases using animal models : Mapping susceptibility genes for multiple sclerosis and rheumatoid arthritis

   Författare :Hai-Tao Yang; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Collagen induced arthritis CIA ; Experimental allergic encephalomyelities EAE ; Multiple sclerosis MS ; Quantitative trait loci QTL ; Rheumatoid arthritis RA ; Linkage analysis; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

   Sammanfattning : Autoimmune diseases such as rheumatoid arthritis and multiple sclerosis are common human diseasesaffecting 1% and 0.1% of the population respectively. These diseases are characterized by abnormal self-tolerance in the immune system and autoimmune reactions. LÄS MER