Sökning: "ABCG5 ABCG5"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden ABCG5 ABCG5.

  1. 1. Studies on cholesterol and bile acid metabolism in Chinese cholesterol gallstone patients

    Författare :Zhao-Yan Jiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cholesterol gallstone disease; ABCG5 ABCG5; SRBI; ACAT2; Gender; Bile acids; Liver; Intestine;

    Sammanfattning : Liver and intestine are important organs for the metabolism of cholesterol and bile acids in the body. Dysfunction in cholesterol and bile acid metabolism may lead to diseases such as cholesterol gallstone (GS) disease and atherosclerosis. LÄS MER

  3. 2. Studies of sterol 12alpha-hydroxylase (CYP8B1) : distribution and role for cholesterol homeostasis and gallstone formation

    Författare :Jin Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CYP8B1; CY7P7A1; bile acid; cholesterol homeostasis; gallstone; nuclear receptor; cellular distribution; cholesterol hypersecretion; ABCG5 G8; SREBP2; cholesterol absorption; diabetes mellitus; anti-atherogenesis;

    Sammanfattning : Bile acids are essential physiological molecules which carry out multiple functions such as facilitating the absorption of dietary lipids and regulating the metabolism of cholesterol and bile acids. The formation of bile represents the major route for elimination of excess cholesterol, either by conversion of cholesterol into bile acids or excretion of intact cholesterol in mixed micelles. LÄS MER

  4. 3. Studies on the effects of thyroid hormone on cholesterol and lipoprotein metabolism

    Författare :Ylva Bonde; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Elevated plasma lipids, particularly cholesterol within low density lipoproteins, is an important risk factor for developing atherosclerosis which can cause angina pectoris, myocardial infarction, and stroke. Thyroid hormone (TH) has a strong influence on lipid metabolism and the aim of this thesis was to gain more insight into how TH modulates cholesterol and lipoprotein metabolism. LÄS MER

  5. 4. Functional study of nuclear receptors and bile acids in the modulation of cholesterol homeostasis

    Författare :Xiaoli Hu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cholesterol carries multiple biological functions in the body, and imbalanced cholesterol metabolism leads to atherosclerosis and cardiovascular diseases. The present thesis aims to extend the knowledge of cholesterol metabolic regulation mediated by nuclear receptor LXRs and bile acids, two major players in the homeostasis of body cholesterol. LÄS MER

  7. 5. Studies on the phenotype of LXRβ-/- mice : from malabsorption to amyotrophic lateral sclerosis

    Författare :Chiara Gabbi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Liver X Receptors, LXRalpha and LXRbeta (NR1H2) are nuclear receptors belonging to the superfamily of ligand-activated transcription factors with a key role in the control of lipid and glucose metabolism. Studies of the phenotype of LXRalpha-/-mice and LXRbeta-/-mice have shown that these nuclear receptors have specific and distinct roles, although they share very high sequence homology (78%). LÄS MER