Sökning: "multiple inhibition kinetics"

Visar resultat 6 - 10 av 11 avhandlingar innehållade orden multiple inhibition kinetics.

  1. 6. Pharmacokinetics and dynamics of atovaquone and proguanil (Malarone®)

    Författare :Mita M Thapar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Malarone; Atovaquone; proguanil; cycloguanil; pharmacokinetics; drug interactions; pharmacodynamics; resistance;

    Sammanfattning : Malarone® is a fixed dose combination of atovaquone and proguanil and is mainly used for prophylaxis against P. falciparum malaria as an alternative to Lariamo® or chloroquine+proguanil. LÄS MER

  3. 7. Modulating the activity of OGG1 using small molecules to target the oxidative DNA damage response in cancer and inflammation

    Författare :Bishoy M F Hanna; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The production of reactive oxygen species (ROS) is increased in several pathological conditions including cancer and inflammation. Multiple lines of evidence suggest that ROS are involved in signaling events that promote tumorigenesis and inflammatory responses. LÄS MER

  4. 8. Studies on early cellular responses during Epstein-Barr virus infection

    Författare :Xinsong Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The human gamma-herpesvirus Epstein-Barr virus (EBV) has been implicated in the pathogenesis of a broad spectrum of lymphoid and epithelial cell malignancies. A characteristic property of the virus is the capacity to establish a non-productive growthpromoting infection in B-lymphocytes. LÄS MER

  5. 9. Development of nonviral gene delivery and of anti-gene reagents

    Författare :Rongbin Ge; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Although significant progress has been made in the basic science and applications of various non-viral gene delivery systems, the majority of non-viral approaches are still much less efficient than viral vectors, especially for in vivo gene delivery, Therefore, non-viral gene delivery must be developed in order to increase the efficiency of in vivo delivery. Moreover, a novel anti-gene reagent was developed for sequence-specific gene silencing. LÄS MER

  7. 10. Influence of oxidative stress on aryl hydrocarbon receptor signaling

    Författare :Afshin Mohammadi Bardbori; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aryl hydrocarbon receptor (AHR), a multifunctional protein and a key regulator of drug metabolizing enzymes, belongs to the basic-helix-loop-helix (bHLH)/PAS (Per-Arnt-Sim) super-family of transcription factors. The AHR responds to exogenous and endogenous chemicals by induction or repression of a large number of genes involved in many physiological processes and normal development. LÄS MER