Sökning: "immortalization"

Visar resultat 21 - 25 av 25 avhandlingar innehållade ordet immortalization.

  1. 21. Telomerase reverse transcriptase (TERT) : promoter mutation and novel function in human cancer

    Författare :Tiantian Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Telomerase reverse transcriptase (TERT) is the catalytic component of telomerase, an RNAdependent DNA polymerase responsible for telomere elongation. TERT is transcriptionally repressed in most normal human somatic cells with limited life-span, which contributes to telomerase silence. LÄS MER

  3. 22. Regulation of the Epstein-Barr virus C promoter by the OriP-EBNA1 complex

    Författare :Cecilia Boreström; Göteborgs universitet; []
    Nyckelord :Epstein-Barr virus; EBNA1; NF-Y; Sp1; Oct-2; Bright; E2F1; transcriptional regulation; Cp; oriP;

    Sammanfattning : Epstein-Barr Virus (EBV) is an exclusively human, lymphotropic herpes virus that infects more than 90% of the population worldwide. Primary infection usually occurs during the early years of life and does not result in any recognized disease. LÄS MER

  4. 23. Epstein-Barr virus (EBV) latent membrane protein (LMP) 2A

    Författare :Fu Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epstein-Barr virus (EBV) is a ubiquitous human herpes virus which infects more than 90% of individuals in the population and is causally implicated in lymphoid and epithelial malignancies. Virus invades oropharyngeal mucosa and establishes latency in memory B lymphocytes. LÄS MER

  5. 24. Immunological consequences of Epstein-Barr virus replication

    Författare :Andre Ortlieb Guerreiro Cacais; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus involved in the pathogenesis of a wide spectrum of malignant and non-malignant diseases. In healthy EBV carriers, the virus is believed to infect two major cellular targets - B lymphocytes and epithelial cells. LÄS MER

  7. 25. Expression and activity of Myc network proteins during cell cycle progression and differentiation

    Författare :Nikita Popov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Transcription factors of Myc network are the key regulators of cell proliferation, cell death and differentiation. Identified as a transforming oncogene, myc is the driving force of a variety of human cancers, and inactivation of myc in tumors can cause their rapid regression. LÄS MER