Sökning: "cholesterol genetic"

Visar resultat 1 - 5 av 90 avhandlingar innehållade orden cholesterol genetic.

1. 1. Genetic Determinants of Dyslipidemia

   Författare :Tibor V Varga; Genetisk och molekylär epidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetic epidemiology; Genetic polymorphism; dyslipidaemia; Cholesterol; Triglyceride; Genetic risk; genetic risk score; Single nucleotide polymorphism; Prediction; Gene-environment interactions; Randomized controlled trial; prospective cohort studies; Observational study; GLACIER Study; Diabetes Prevention Program;

   Sammanfattning : Dyslipidemia is a chronic deviation from normal blood lipid levels that can lead to atherosclerosis and other cardiovascular diseases; dyslipidemia and its sequelae are caused by the complex interplay of genetic and environmental factors. Although circulating concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (LDL-C) have a strong genetic underpinning, not much is known about the genetic factors that affect long-term deteriorations in lipid concentrations. LÄS MER

3. 2. Zebrafish models for large-scale genetic screens in dyslipidemia and atherosclerosis : Validation and application

   Författare :Manoj Kumar Bandaru; Marcel den Hoed; Anastasia Emmanouilidou; Ingelsson Erik; Shannon Fisher; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; zebrafish; dyslipidemia; atherosclerosis; genetic screens; high-cholesterol diet; APOE; APOB; LDLR; APOC2; PCSK9; LPAR2; GATAD2A; Medicinsk genetik; Medical Genetics;

   Sammanfattning : Hundreds of loci have been robustly associated with circulating lipids, atherosclerosis and coronary artery disease; but for most loci the causal genes and mechanisms remain uncharacterized. The overall aim of my thesis is to develop and validate novel in vivo model systems that are suitable for high-throughput, image-based genetic screens in coronary artery disease and related traits, and use these model systems to systematically characterize positional candidate genes. LÄS MER

4. 3. Genetic and non-genetic influences on some metabolic cardiovascular risk factors : quantitative genetic analyses

   Författare :Yuling Hong; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cardiovascular risk factors; heritability; twins; adoption; insulin resistance syndrome; IGF-I; IGFBP-I; PAI-l; blood pressure; triglycerides; Lp a ; obesity.;

   Sammanfattning : Structural-equation modeling analyses were applied to data from 302 Swedish twin pairs in order to assess the relative importance of genetic and nongenetic influences on several metabolic cardiovascular risk factors. These middle-aged and elderly twins include monozygotic and dizygotic twins reared apart and together, who came from a population-based national twin register. LÄS MER

5. 4. Coffee and gene interaction. The effect on methionine and lipid metabolism

   Författare :Elisabeth Strandhagen; Göteborgs universitet; []
   Nyckelord :coffee; homocysteine; cholesterol; folate; pyridoxine; MTHFR; APOE; gene; polymorphism; interaction;

   Sammanfattning : Background: Different dietary factors influence the risk of coronary heart disease (CHD), most likely in an interaction with genetic polymorphisms. The knowledge about such interactions is insufficient. Some observational studies have shown an association between coffee and CHD, others have not. Coffee consumption affects some CHD risk factors, e. LÄS MER

7. 5. Molecular mechanisms in obesity-associated metabolic disease

   Författare :Louise Olofsson; Göteborgs universitet; []
   Nyckelord :obesity; metabolic syndrome; cholesterol; resting metabolic rate; insulin resistance; serum amyloid A; S100 calcium binding protein A1; Zn-alpha2-glycoprotein; CCAAT enhancer binding protein alpha;

   Sammanfattning : Obesity is associated with increased morbidity and mortality. Subjects with obesity are at risk of developing several serious conditions such as type 2 diabetes, hypertension, coronary heart disease and stroke. LÄS MER