Sökning: "cecilia karolinska"

Visar resultat 21 - 25 av 69 avhandlingar innehållade orden cecilia karolinska.

  1. 21. Mechanistic characterization of post-transcriptional gene silencing

    Författare :Cecilia Dahlgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : With the ongoing task of identifying and characterizing genes in the human genome, there is a great demand for tools to study these genes. Today, reverse genetics is the most effective way to explore gene function. This involves suppression of the gene of interest by a set of manipulation techniques. LÄS MER

  3. 22. Heritability and sex differences in experimental neuropathic pain with special emphasis on the role of the major histocompatibility complex

    Författare :Cecilia Dominguez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuropathic pain caused by injury to the nervous system is a difficult clinical problem and a large proportion of patients experience no or only partial relief from existing treatments. Pain sensitivity and the development of neuropathic pain are complex biological and physiological entities that are known to be affected by genetics and sex. LÄS MER

  4. 23. Targeting dysfunctional developmental signaling cascades as a tool for tailored therapy in embryonal tumors

    Författare :Cecilia Dyberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroblastoma and medulloblastoma are embryonal malignant tumors of the central and peripheral nervous systems, respectively. The overall survival for both diagnoses is 60-75% despite intense multimodal therapy. This warrants the search for novel therapeutic approaches. LÄS MER

  5. 24. In vitro models of xenograft rejection : studies on leukocyte-endothelial cell interactions

    Författare :Cecilia Ehrnfelt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Xenotransplantation; endothelium; neutrophils; monocytes; NK cells; a-Gal; antibodies; porcine islets; MCP-1;

    Sammanfattning : Xenotransplantation is the transplantation of cells, tissues or organs between different species and is a potential alternative to allotransplantation because of the lack of human donors. The pig is believed to be a suitable donor-species to man for medical, technical, financial and ethical reasons. LÄS MER

  7. 25. Teenage parenthood : paternal characteristics and child health outcomes

    Författare :Cecilia Ekéus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis had two general aims. The first was to describe and compare the social-economic and reproductive characteristics and involvement in pregnancy and childbirth of fathers of children born to teenage mothers in Stockholm (Papers I and II). LÄS MER