Sökning: "Insulin-Like Growth Factor I"

Visar resultat 6 - 10 av 164 avhandlingar innehållade orden Insulin-Like Growth Factor I.

1. 6. Cardiovascular effects of growth hormone, IGF-I and growth hormone secretagogues

   Författare :Åsa Tivesten; Göteborgs universitet; []
   Nyckelord :cardiovascular system; growth hormone; insulin-like growth factor-I; growth hormone secretagogues; echocardiography.;

   Sammanfattning : Growth hormone (GH) may exert direct growth-promoting and metabolic actions on target tissues, but most of its effects are mediated by circulating (endocrine) or local (auto-/paracrine) insulin-like growth factor-I (IGF-I). The GH/IGF-I system has an important role during cardiac development and for maintaining the structure and function of the heart. LÄS MER

3. 7. Experimental studies on the effects of insulin-like growth factor I and glucocorticoids on bone metabolism

   Författare :Kenneth B. Jonsson; Uppsala universitet; []
   Nyckelord :Medical sciences; Bone; bone resorption; glucocorticoids; insulin-like growth factor I; osteoblasts; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

   Sammanfattning : Osteoporosis is a major cause of disability among patients that are dependent on glucocorticoids in the treatment of inflammatory disease. The pathogenesis behind this side effect is complex, involving dysregulation of hormonal systems and direct effects on bone cells. LÄS MER

4. 8. Proteolysis of insulin-like growth factor-binding protein-1, -2 and -4 : function of fragments

   Författare :Katrin Brandt; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Insulin-like growth factor;

   Sammanfattning : The insulin-like growth factors (IGF-I and IGF-II) stimulate cell growth, survival and differentiation, and have insulin-like activity. A family of six IGF-binding proteins (IGFBP-1 through -6) bind to IGFs with high affinity and modulate their activity in the circulation and locally at cell-surface receptors. LÄS MER

5. 9. Prolactin and growth hormone in breast cancer. Studies of human breast cancer and transgenic tumor models

   Författare :Maria Gebre-Medhin; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prolactin; growth hormone; breast cancer; transgenic mice; estrogen receptor; insulin-like growth factor; insulin-like growth factor-I receptor;

   Sammanfattning : Prolactin (PRL) and growth hormone (GH) are two related pituitary peptide hormones of importance during normal mammary gland development. Furthermore, their involvement in development and growth of malignant mammary tumors has been suggested by several investigators. LÄS MER

7. 10. Targeting insulin-like growth factor-1 receptor in cancer

   Författare :Ada Girnita; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IGF1; IGF-1R; MDM2; p53; PPP; Tamoxifen; tyrosine kinase inhibitors; ubiquitin;

   Sammanfattning : Cancer is a multi-step process where the accumulation of several genetic and epigenetic alterations drives the transformation of a normal cell to a malignant cell, skipping the normal control of defense, repair and apoptosis. During the selection process towards a malignant phenotype, the transforming cells make use of normal (physiological) extracellular signaling pathways to create growth advantage over normal cells. LÄS MER