Sökning: "zinc-containing peptidase"

Hittade 2 avhandlingar innehållade orden zinc-containing peptidase.

  1. 1. Theoretical Modeling of Enzyme Catalysis with Focus on Radical Chemistry

    Författare :Vladimir Pelmenschikov; Per E. M. Siegbahn; Tim Clark; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; density functional theory; enzyme catalysis; radical chemistry; zinc-containing peptidase; methyl-coenzyme M reductase; ribonucleotide reductase; superoxide dismutase; Quantum chemistry; Kvantkemi;

    Sammanfattning : Hybrid density functional theory (DFT) B3LYP method is applied to study the four diverse enzyme systems: zinc-containing peptidases (thermolysin and stromelysin), methyl-coenzyme M reductase, ribonucleotide reductases (classes I and III), and superoxide dismutases (Cu,Zn- and Ni-dependent enzymes). Powerfull tools of modern quantum chemistry are used to address the questions of biological pathways at their molecular level, proposing a novel mechanism for methane production by methyl-coenzyme M reductase and providing additional insights into hydrolysis by zinc peptidases, substrate conversion by ribonucleotide reductases, and biological superoxide dismutation. LÄS MER

  3. 2. Evolution and structure of leukotriene A4 hydrolase

    Författare :Filippa Kull; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukotriene (LT) B4 is a potent leukocyte chemotactic and aggregating agent involved in a variety of inflammatory and allergic disorders. The enzyme leukotriene A4 hydrolase catalyzes the hydrolysis of LTA4 into this proinflammatory mediator, leukotriene B4. LÄS MER