Sökning: "zinc motif"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden zinc motif.

  1. 1. The ABC of KRAB zinc finger proteins

    Författare :Camilla Looman; Lars Hellman; Lars-Gunnar Larsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Krüppel zinc finger; KRAB; transcription; repression; evolution; Biologi; Biology; Biologi; immunologi; Immunology;

    Sammanfattning : All living organisms consist of cells and the identity of a cell is defined by the genes it expresses. To assure proper function, a cell receives continuous information on which genes to turn on and off. This information is, to a large extent, provided by transcription factors. LÄS MER

  3. 2. Three Subfamilies of KRAB Zinc Finger Proteins : A Structural, Functional and Evolutionary Analysis

    Författare :Charlotta Mark; Lars Hellman; Fredrik Öberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Krüppel zinc finger; KRAB; TIF1β; transcriptional repression; Biologi; Biology; Biologi; Molecular Immunology; molekylär immunologi;

    Sammanfattning : Krüppel-related zinc finger proteins constitute the largest single class of transcription factors within the human genome. Members of this protein family have the ability to either activate or repress transcription depending on the presence of specific activator or repressor domains within the protein. LÄS MER

  4. 3. Structural and Functional Studies of Wilms Tumour Protein - WT1; Novel Insights into Functionality of Zinc Finger Proteins

    Författare :Elmar Nurmemmedov; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Naturvetenskap; Natural science; function; structure; transcription factor; cancer; affinity; kinetics; Biacore; RNA binding; DNA binding; Wilms tumour WT1 ; zinc finger;

    Sammanfattning : The molecular process under which message in DNA is relayed onto RNA is called transcription, and it accomplished through involvement of so-called transcription factors. Zinc finger proteins are one of the most abundant classes of regulatory proteins in eukaryotic cells where they play central roles in a variety of cellular activities. LÄS MER

  5. 4. Development of improved nuclear magnetic resonance techniques and structure determination of a zinc finger peptide

    Författare :Anna Hammarström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Since the functions of biological molecules are closely related to their structures, obtaining the three-dimensional structures is of great importance to the understanding of biology. Currently, the only two methods that can be used for protein structure determination at atomic resolution are X-ray crystallography and NMR spectroscopy. LÄS MER

  7. 5. Evolution and structure of leukotriene A4 hydrolase

    Författare :Filippa Kull; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukotriene (LT) B4 is a potent leukocyte chemotactic and aggregating agent involved in a variety of inflammatory and allergic disorders. The enzyme leukotriene A4 hydrolase catalyzes the hydrolysis of LTA4 into this proinflammatory mediator, leukotriene B4. LÄS MER