Sökning: "xenograft model"
Visar resultat 1 - 5 av 90 avhandlingar innehållade orden xenograft model.
1. Xenograft Rejection : A Study of Cytokine mRNA Expression in Experimental Models
Sammanfattning : Acute cellular xenograft rejection of ICCs triggered mRNA expression of proinflammatory cytokines (IL-1b and TNF-a), Th1 associated cytokines (IL-12p40, IL-2 and IFN-g) and Th2 associated cytokines (IL-4 and IL-10). The peak values and the kinetics of the mRNA expression indicated that acute cellular xenograft rejection is enhanced by the proinflammatory response and mediated by the Th1 associated response, whereas the function of the Th2 associated response most likely is to counteract the Th1 associated cytokines and thereby inhibit bystander damage by the delayed type hypersensitivity like rejection process. LÄS MER
2. Experimental studies on xenograft rejection
Sammanfattning : The use of animal organs and tissues may provide a solution to the severe and worsening shortage of human grafts. The aims of the present experimental studies were to provide a better understanding of the rejection mechanisms and give new clues for prevention of xenorejection, thereby hopefully contributing to the development of clinical xenotransplantation. LÄS MER
3. Pancreatic Cancer - Early Detection, Prognostic Factors, and Treatment
Sammanfattning : Background: Pancreatic cancer is the fourth leading cause of cancer-related death. Only about 6% of patients are alive 5 years after diagnosis. One reason for this low survival rate is that most patients are diagnosed at a late stage, when the tumor has spread to surrounding tissues or distant organs. LÄS MER
4. The involvement of gangliosides in growth and migration of human glioblastoma cells
Sammanfattning : Human glioblastoma is a primary brain tumour with a bad prognosis. One major contributing factor is that the tumour grows in an infiltrative way. Single tumour cells, undetectable with today's techniques, invade the brain and escape therapy. LÄS MER
5. Restoration of scarred vocal folds with stem cell implantation : analyses in a xenograft model
Sammanfattning : Background: Tissue defects in the vocal fold (VF) caused by trauma, surgical procedures, post radiotherapy, often heal with scar formation. The scar tissue causes stiffness of the lamina propria rendering disturbed viscoelastic properties to the VF. A scarred VF causes severe voice problems. LÄS MER