Sökning: "whole-genome"

Visar resultat 1 - 5 av 256 avhandlingar innehållade ordet whole-genome.

  1. 1. Whole Genome Sequencing of Enterotoxigenic Escherichia coli

    Författare :Astrid von Mentzer; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ETEC; whole genome sequencing; evolution; colonization factor; reverse genetics;

    Sammanfattning : Enterotoxigenic Escherichia coli (ETEC) infections are a common cause of diarrhea but little is known about the evolution and genomic composition of ETEC. The main aim of this thesis was to generate a large collection of whole genome sequenced ETEC isolates to study the evolution of such bacteria on a global level and to search for novel colonization factors (CFs) using both classical and cutting-edge genomic techniques. LÄS MER

  3. 2. Evolution of Vertebrate Vision by Means of Whole Genome Duplications : Zebrafish as a Model for Gene Specialisation

    Författare :David Lagman; Dan Larhammar; Xesús M Abalo; Finn Hallböök; Stephan Neuhauss; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; phylogenetics; evolution; vision; visual opsin; transducin; PDE6; genome duplications; subfunctionalisation; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The signalling cascade of rods and cones use different but related protein components. Rods and cones, emerged in the common ancestor of vertebrates around 500 million years ago around when two whole genome duplications took place, named 1R and 2R. LÄS MER

  4. 3. Characterizing the spectrum of somatic alterations in canine and human cancers

    Författare :Sharadha Sakthikumar; Kerstin Lindblad-Toh; Richard Rosenquist Brandell; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dog; osteosarcoma; hemangiosarcoma; glioblastoma; non-coding; whole-exome; whole-genome; sequencing; bioinformatics; comparative genetics.;

    Sammanfattning : Cancers arise as a result of deleterious somatic alterations accumulating in the genome during the process of cell division. These alterations arise either via exposure to mutagens or due to errors occurring during DNA replication. LÄS MER

  5. 4. Inferring demographic history and speciation of grouse using whole genome sequences

    Författare :Radoslav Kozma; Jacob Höglund; Jeff A. Johnson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Demographic history; speciation; effective population size; adaptation; willow grouse; red grouse; black grouse; rock ptarmigan; Tetraoninae; conservation genetics; climate change; PSMC; species distribution modelling; FOXP4; Agouti;

    Sammanfattning : From an ecological perspective, knowledge of demographic history is highly valuable because population size fluctuations can be matched to known climatic events, thereby revealing great insight into a species’ reaction to past climate change. This in turn enables us to predict how they might respond to future climate scenarios. LÄS MER

  7. 5. From Single Gene to Whole Genome Studies of Human Transcription Regulation

    Författare :Alvaro Rada-Iglesias; Claes Wadelius; Henk Stunnenberg; Uppsala universitet; []
    Nyckelord :Genetics; transcription; ChIP-chip; genome-wide; transcription factors; in vivo; Genetik;

    Sammanfattning : Transcriptional regulation largely determines which proteins and the protein levels that are found in a cell, and this is crucial in development, differentiation and responses to environmental stimuli. The major effectors of transcriptional regulation are a group of proteins known as transcription factors, which importance is supported by their frequent involvement in mendelian and complex diseases. LÄS MER