Sökning: "whole genome microarray"
Visar resultat 21 - 25 av 40 avhandlingar innehållade orden whole genome microarray.
21. Manifold Learning in Computational Biology
Sammanfattning : This thesis deals with manifold learning techniques and their application in gene expression data analysis. Manifold learning is the study of methods that aim to infer geometrical structure from data sampled from manifolds, enabling nonlinear solutions to various machine learning tasks. LÄS MER
22. Genetic content of clinical pneumococcal isolates and its relation to disease outcome
Sammanfattning : Streptococcus pneumoniae is a Gram-positive bacterium that can cause a wide range of diseases. These include otitis media, sinusitis, pneumonia and meningitis. It can, however, also cause asymptomatic carriage thereby behaving almost like a commensal. LÄS MER
23. Transcriptome and Proteome Analysis using Signature Tags
Sammanfattning : With the full sequence of the human genome now available, anexciting era in biomedical research has started. The sequenceprovides information about all our genes and greatly increasesthe scope to compare genetic activities in different cells, toanalyze genetic variation between individuals and betweendifferent species and, most importantly, to investigatesystematically the whole genome in a gene-by-gene manner, andthus increase our understanding of gene function. LÄS MER
24. Comprehensive analysis of structural genomic alterations in cancer : Computational approaches for identifying cancer driver events
Sammanfattning : The transformation of a normal cell into a cancer cell involves the accumulation of somatic DNA alterations that confer growth and survival advantages. These genomic alterations can be different in terms of pattern and size, comprising single nucleotide variants (SNVs), small insertions or deletions (indels), structural variations (SVs) or foreign DNA insertions such as viral DNA. LÄS MER
25. Gene dose imbalances in children with mental retardation
Sammanfattning : Submicroscopic chromosome aberrations can cause mental retardation (MR), congenital malformations and miscarriage. It is difficult to estimate the contribution of cytogenetic abnormalities to MR because of relatively low detection sensitivity of conventional cytogenetic methods used in the diagnostic setting. LÄS MER