Sökning: "whole genome amplification"

Visar resultat 16 - 20 av 30 avhandlingar innehållade orden whole genome amplification.

1. 16. Mechanisms behind growth of castration-resistant prostate cancer bone metastases

   Författare :Emma Jernberg; Pernilla Wikström; Jack Schalken; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; castration-resistance; bone metastases; androgen receptor; intratumoral steroidogenesis; androgen receptor splice variants; androgen receptor amplification; patologi; Pathology;

   Sammanfattning : Background: The first-line treatment for patients with advanced prostate cancer (PC) is androgen deprivation therapy. This therapy is initially effective, but after some time tumors relapse, predominantly within the bone, and are then termed castration-resistant prostate cancer (CRPC). LÄS MER

3. 17. Molecular diagnosis of infection with Toxoplasma gondii in immunocompromised patients

   Författare :Benjamin Edvinsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Toxoplasma gondii; toxoplasmosis; transplantation; human immunodeficiency virus; polymerase chain reaction; internal amplification control; oligochromatography; Pyrosequencing;

   Sammanfattning : The protozoan parasite Toxoplasma gondii infects more than a billion people worldwide. The parasite is generally divided into three clonal lineages, denoted type I, II and III. LÄS MER

4. 18. Genomic characterization of pediatric acute lymphoblastic leukemia by deep sequencing

   Författare :Carl Mårten Lindqvist; Ann-Christine Syvänen; Gabor Marth; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Acute Lymphoblastic Leukemia (ALL) is the most common cancer in children, with close to 200 cases per year in the Nordic countries. Despite recent advances in modern chemotherapies, 20% of the ALL patients experience a relapse. LÄS MER

5. 19. Genetic studies of acute lymphoblastic leukemia

   Författare :Ekaterina Kuchinskaya; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, comprising approximately 25% of all childhood cancers. A huge improvement in outcome of children with ALL during the last 20 years has resulted in remission rates exceeding 95% and a 5 year event-free-survival approaching 80%. LÄS MER

7. 20. Extracting Genomic Variations using Selector Technology

   Författare :Magnus Isaksson; Mats Nilsson; Radoje Drmanac; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Selector; Selector probe; Genetic variation; Resequencing; Targeted sequencing; copy-number variations; MLGA; Bioinformatics; Next generation sequencing; NGS; Amplified single molecule; ASM; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Genetics; Genetik; Molekylär medicin; Molecular Medicine;

   Sammanfattning : This thesis describes the development and use of a new class of molecular tools called Selector probes, and its potential for investigations of genetic variation. The Selector technology provides multiplex amplification of targeted DNA sequences with a high specificity, and an enrichment factor in the same order of magnitude as PCR. LÄS MER