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Visar resultat 1 - 5 av 30 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Modeling Genome Evolution : Creation, Change and Destruction

    Författare :Mats Pettersson; Otto Berg; Paul Sniegowski; Uppsala universitet; []
    Nyckelord :Molecular biology; Theotretical biology; Population genetics; Stochastic modeling; Genome evolution; Molekylärbiologi;

    Sammanfattning : Historically, evolution has been studied either by looking at morphological traits in living organisms and the fossil record, or by using bioinformatics and comparative genomics. While highly useful for deducing evolutionary history, these approaches are not particularly well suited for studying the mechanisms of evolution. LÄS MER

  3. 2. Technologies for Single Cell Genome Analysis

    Författare :Erik Borgström; Afshin Ahmadian; Sten Linnarsson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA; sequencing; single molecule; single cell; whole genome amplification; exome sequencing; emulsions; barcoding; phasin; Biotechnology; Bioteknologi;

    Sammanfattning : During the last decade high throughput DNA sequencing of single cells has evolved from an idea to one of the most high profile fields of research. Much of this development has been possible due to the dramatic reduction in costs for massively parallel sequencing. LÄS MER

  4. 3. Consequences of the Domestication of Man’s Best Friend, The Dog

    Författare :Susanne Björnerfeldt; Carles Vilà; Elena Jazin; Daniel Bradley; Uppsala universitet; []
    Nyckelord :Molecular genetics; mitochondrial genome; Y chromosome; microsatellites; disruptive selection; breed structure; whole genome amplification; gene flow; linkage disequilibrium; Canis familiaris; Canis lupus; Genetik;

    Sammanfattning : The dog was the first animal to be domesticated and the process started at least 15 000 years ago. Today it is the most morphologically diverse mammal, with a huge variation in size and shape. LÄS MER

  5. 4. Massively parallel analysis of cells and nucleic acids

    Författare :Julia Sandberg; Joakim Lundeberg; Nader Pourmand; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Massively parallel sequencing; 454; Illumina; multiplex amplification; whole genome amplification; single cell; polyguanine; flow-cytometry;

    Sammanfattning : Recent proceedings in biotechnology have enabled completely new avenues in life science research to be explored. By allowing increased parallelization an ever-increasing complexity of cell samples or experiments can be investigated in shorter time and at a lower cost. LÄS MER

  7. 5. Analysis of Nucleotide Variations in Non-human Primates

    Författare :Ann-Charlotte Rönn; Ann-Christine Syvänen; Mats Nilsson; Phillip Morin; Uppsala universitet; []
    Nyckelord :Molecular genetics; SNP; genotyping; primate; chimpanzee; whole genome amplification; multiple displacement amplification; minisequencing; microarray; Y-chromosome; mitochondria; Genetik;

    Sammanfattning : Many of our closest relatives, the primates, are endangered and could be extinct in a near future. To increase the knowledge of non-human primate genomes, and at the same time acquire information on our own genomic evolution, studies using high-throughput technologies are applied, which raises the demand for large amounts of high quality DNA. LÄS MER