Sökning: "wesley"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet wesley.

  1. 1. Lifestyle matters : epidemiological studies of oily fish, BMI, life events, physical workload and rheumatoid arthritis

    Författare :Annmarie Wesley; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Rheumatoid Arthritis;

    Sammanfattning : Rheumatoid arthritis (RA), divided in two major subsets defined by presence or absence of anti-citrullinated protein antibodies (ACPA), is chronic inflammatory disease which lead to joint damage and bone destruction. It is a complex disease where both genetic and environmental factors contribute to its development. LÄS MER

  3. 2. Computational Studies of HIV-1 Protease Inhibitors

    Författare :Wesley Schaal; Garland Marshall; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; HIV Protease; 3D-QSAR; CoMFA; Molecular Modelling; Force Field Parameterization; Quantum Mechanics; DFT; Enzyme Kinetics; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; Organisk farmaceutisk kemi;

    Sammanfattning : Human Immunodeficiency Virus (HIV) is the causative agent of the pandemic disease Acquired Immune Deficiency Syndrome (AIDS). HIV acts to disrupt the immune system which makes the body susceptible to opportunistic infections. Untreated, AIDS is generally fatal. LÄS MER

  4. 3. Confidence Predictions in Pharmaceutical Sciences

    Författare :Staffan Arvidsson McShane; Ola Spjuth; Wesley Schaal; Lars Carlsson; Ernst Ahlberg; Stefan Kramer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; machine learning; QSAR; Conformal prediction; Venn-ABERS; Probabilistic machine learning; Machine learning; Maskininlärning; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The main focus of this thesis has been on Quantitative Structure Activity Relationship (QSAR) modeling using methods producing valid measures of uncertainty. The goal of QSAR is to prospectively predict the outcome from assays, such as ADMET (Absorption, Distribution, Metabolism, Excretion), toxicity and on- and off-target interactions, for novel compounds. LÄS MER

  5. 4. Assessing inbreeding and loss of genetic variation in canids, domestic dog (Canis familiaris) and wolf (Canis lupus), using pedigree data

    Författare :Mija Jansson; Linda Laikre; Liselotte Andersen Wesley; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; populationsgenetik; Population Genetics;

    Sammanfattning : Genetic variation is necessary to maintain the ability of wild and domestic populations to genetically adapt to changed selective pressures. When relationships among individuals are known, conservation genetic management can be based on statistical pedigree analysis. LÄS MER

  7. 5. The “Dark Side” of Marine Spatial Planning : A study of domination, empowerment and freedom through theories of discourse and power

    Författare :Ralph Voma Tafon; Michael Gilek; Fred P. Saunders; Wesley Flannery; Södertörns högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; marine spatial planning; discourse; power; domination; empowerment; freedom; conflict; resistance; small-scale fisheries; offshore wind energy; Environmental Studies; Miljövetenskapliga studier; Östersjö- och Östeuropaforskning; Baltic and East European studies;

    Sammanfattning : This thesis aims to contribute to the marine spatial planning (MSP) literature by elaborating a robust theoretical account of power for a more rigorous and balanced critical analysis of MSP. Conceived as a problem-solving regime, MSP has emerged as a radical approach to govern the use and protection of marine resources. LÄS MER