Sökning: "voltage-gated calcium channels"

Visar resultat 1 - 5 av 26 avhandlingar innehållade orden voltage-gated calcium channels.

  1. 1. Targeting the voltage-gated calcium channels as treatment for type 2 diabetes

    Författare :Pawel Buda; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autophagy; apoptosis; calcium channels; Type 2 Diabetes;

    Sammanfattning : L-type voltage-gated Ca2+ channels are expressed in the plasma membrane of muscles, neurons and endocrine cells where they serve as conductors of signals regulating cellular responses to changes in environment. Malfunctions of channels, as well as deregulations of their activity underlie numerous disorders and diseases commonly called channelopathies. LÄS MER

  2. 2. New aspects of voltage-gated calcium channel regulation in pancreatic beta-cells - Relevance for insulin release and type 2 diabetes

    Författare :Thomas Reinbothe; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; voltage-gated calcium channels; L-type; insulin secretion; type 2 diabetes;

    Sammanfattning : Voltage-gated Ca2+ channels are essential transducers of cellular signals in many electrically excitable cells. In the pancreatic beta-cell they mediate controlled Ca2+ influx, which is the final trigger for Ca2+ dependent release (exocytosis) of the blood glucose lowering hormone insulin. LÄS MER

  3. 3. Calcium transport in the Pacific oyster, Crassostrea gigas - in a changing environment

    Författare :Kirsikka Sillanpää; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Climate changes; Ussing chambers; Calcium uptake; Sodium potassium ATPase; Calcium ATPase; Sodium calcium exchanger; Calcium channel; Hemocytes; Mantle epithelium;

    Sammanfattning : Pacific oyster, Crassostrea gigas, is globally one of the most important farmed bivalve species. A prominent features of the C. gigas is the thick CaCO3 shell covering the body of the animal and protecting it from the environment. LÄS MER

  4. 4. Site and Mechanism of Action of Resin Acids on Voltage-Gated Ion Channels

    Författare :Malin Silverå Ejneby; Fredrik Elinder; Johan Brask; Dirk Snyders; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Voltage-gated ion channels are pore-forming membrane proteins that open or close their gates when the voltage across the membrane is changed. They underlie the electrical activity that enables the heart to pump blood and the brain to receive and send signals. LÄS MER

  5. 5. The Best Leading Role for Maintaining Normal β-cell Function Goes to MafA and Voltage-gated Calcium Channel Subunit γ4

    Författare :Cheng Luan; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; insulin secretion; pancreatic islet; MafA; CaVγ4; CaV channels; β-cell function; dedifferentiation; transcription factor; patch clamp; Ca2 signaling; cholinergic nicotinic receptor; ChrnB4; GDF11; aging; islet inflammation; maturation;

    Sammanfattning : .... LÄS MER